期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 25, 期 23, 页码 10973-10979出版社
WILEY
DOI: 10.1111/jcmm.17018
关键词
carotid artery atherosclerosis; CIBERSORT; immune infiltration; M2 macrophages; unstable atherosclerosis
资金
- National Natural Science Foundation of China [81470723]
- Clinical Medicine Science and Technology Special Project of Jiangsu Province [BL2014083]
- Science and Technology Plan Project of Nanjing [201803064]
This study compared the abundance and difference of specific immune cell subgroups in unstable atherosclerotic tissues, revealing a dominance of M2 macrophages, M0 macrophages, CD4 memory T cells, and CD8 T cells in the immune cell landscape of atherosclerosis. Unstable plaques showed a higher percentage of M2 macrophages compared to stable plaques. Additionally, correlation analysis suggested strong associations between certain immune cell types, such as naive CD4 T cells with gamma delta T cells and memory B cells with plasma cells.
Atherosclerotic plaque instability contributes to ischaemic stroke and myocardial infarction. This study is to compare the abundance and difference of immune cell subtypes within unstable atherosclerotic tissues. CIBERSORT was used to speculate the proportions of 22 immune cell types based on a microarray of atherosclerotic carotid artery samples. R software was utilized to illustrate the bar plot, heat map and vioplot. The immune cell landscape in atherosclerosis was diverse, dominated by M2 macrophages, M0 macrophages, resting CD4 memory T cells and CD8 T cells. There was a significant difference in resting CD4 memory T cells (p = 0.032), T cells follicular helper (p = 0.033), M0 (p = 0.047) and M2 macrophages (p = 0.012) between stable and unstable atherosclerotic plaques. Compared with stable atherosclerotic plaques, unstable atherosclerotic plaques had a higher percentage of M2 macrophages. Moreover, correlation analysis indicated that the percentage of naive CD4 T cells was strongly correlated with that of gamma delta T cells (r = 0.93, p < 0.001), while memory B cells were correlated with plasma cells (r = 0.85, p < 0.001). In summary, our study explored the abundance and difference of specific immune cell subgroups at unstable plaques, which would aid new immunotherapies for atherosclerosis.
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