期刊
JOURNAL OF CELL SCIENCE
卷 134, 期 22, 页码 -出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.258989
关键词
Animal rhodopsin; Microbial rhodopsin; Optogenetics; Photocycle; Retinal; Rhodopsin structure
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) KAKENHI [JP20H05758]
- Japan Society for the Promotion of Science (JSPS) KAKENHI [JP21H01875, JP20K21383, JP20K21416]
- Japan Science and Technology Agency (JST) PRESTO [JPMJPR1888]
Rhodopsins are a class of photoreceptive membrane proteins with a diverse range of functions, including microbial and animal rhodopsins. They exhibit distinctive characteristics in terms of function, structure, color discrimination mechanisms, and optogenetic applications, with a third rhodopsin family known as heliorhodopsin.
Rhodopsins are photoreceptive membrane proteins consisting of a common heptahelical transmembrane architecture that contains a retinal chromophore. Rhodopsin was first discovered in the animal retina in 1876, but a different type of rhodopsin, bacteriorhodopsin, was reported to be present in the cell membrane of an extreme halophilic archaeon, Halobacterium salinarum, 95 years later. Although these findings were made by physiological observation of pigmented tissue and cell bodies, recent progress in genomic and metagenomic analyses has revealed that there are more than 10,000 microbial rhodopsins and 9000 animal rhodopsins with large diversity and tremendous new functionality. In this Cell Science at a Glance article and accompanying poster, we provide an overview of the diversity of functions, structures, color discrimination mechanisms and optogenetic applications of these two rhodopsin families, and will also highlight the third distinctive rhodopsin family, heliorhodopsin.
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