期刊
JOURNAL OF BIOPHOTONICS
卷 15, 期 2, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.202100236
关键词
dermal-epidermal junction; healthy skin; keratinocytes quantification; layer thicknesses; LC-OCT; non-invasive 3D imaging
资金
- Fonds Erasme
This study utilized LC-OCT technology for quantitative analysis of epidermal three-dimensional topography, revealing variations in epidermal metrics across different body sites, and observing real-time evidence of keratinocyte maturation process.
Epidermal three-dimensional (3D) topography/quantification has not been completely characterized yet. The recently developed line-field confocal optical coherence tomography (LC-OCT) provides real-time, high-resolution, in-vivo 3D imaging of the skin. This pilot study aimed at quantifying epidermal metrics (epidermal thicknesses, dermal-epidermal junction [DEJ] undulation and keratinocyte number/shape/size) using 3D LC-OCT. For each study participant (8 female, skin-type-II, younger/older volunteers), seven body sites were imaged with LC-OCT. Epidermal metrics were calculated by segmentations and measurements assisted by artificial intelligence (AI) when appropriate. Thicknesses of epidermis/SC, DEJ undulation and keratinocyte nuclei volume varied across body sites. Evidence of keratinocyte maturation was observed in vivo: keratinocyte nuclei being small/spherical near the DEJ and flatter/elliptical near the skin surface. Skin microanatomy can be quantified by combining LC-OCT and AI. This technology could be highly relevant to understand aging processes and conditions linked to epidermal disorders. Future clinical/research applications are to be expected in this scenario.
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