相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Structural basis for strand-transfer inhibitor binding to HIV intasomes
Dario Oliveira Passos et al.
SCIENCE (2020)
Recent Advances in the Development of Integrase Inhibitors for HIV Treatment
Jay Trivedi et al.
CURRENT HIV/AIDS REPORTS (2020)
A phase 1 trial of itacitinib, a selective JAK1 inhibitor, in patients with acute graft-versus-host disease
Mark A. Schroeder et al.
BLOOD ADVANCES (2020)
Integrase Inhibitors: After 10 Years of Experience, Is the Best Yet to Come?
Kristina M. Brooks et al.
PHARMACOTHERAPY (2019)
Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease
Michael F. Egan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
DrugBank 5.0: a major update to the DrugBank database for 2018
David S. Wishart et al.
NUCLEIC ACIDS RESEARCH (2018)
Integrase inhibitor-based regimens result in more rapid virologic suppression rates among treatment-naive human immunodeficiency virus-infected patients compared to non-nucleoside and protease inhibitor-based regimens in a real-world clinical setting A retrospective cohort study
Karen Jacobson et al.
MEDICINE (2018)
QSAR-Based Virtual Screening: Advances and Applications in Drug Discovery
Bruno J. Neves et al.
FRONTIERS IN PHARMACOLOGY (2018)
Platform for Unified Molecular Analysis: PUMA
Mariana Gonzalez-Medina et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
The Necessary Nitrogen Atom: A Versatile High-Impact Design Element for Multiparameter Optimization
Lewis D. Pennington et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Quantitative structure-activity relationships study of potent pyridinone sca r old derivatives as HIV-1 integrase inhibitors with therapeutic applications
Abolfazl Barzegar et al.
JOURNAL OF THEORETICAL & COMPUTATIONAL CHEMISTRY (2017)
HIV drug resistance against strand transfer integrase inhibitors
Kaitlin Anstett et al.
RETROVIROLOGY (2017)
Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome
Dario Oliveira Passos et al.
SCIENCE (2017)
Developing 2D-QSAR models for naphthyridine derivatives against HIV-1 integrase activity
Mostafa Zakariazadeh et al.
MEDICINAL CHEMISTRY RESEARCH (2015)
Ruxolitinib and Tofacitinib Are Potent and Selective Inhibitors of HIV-1 Replication and Virus Reactivation In Vitro
Christina Gavegnano et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)
Stabilization of the integrase-DNA complex by Mg2+ ions and prediction of key residues for binding HIV-1 integrase inhibitors
Lamia Miri et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2014)
Insights into the drug resistance induced by the BaDHPS mutations: molecular dynamic simulations and MM/GBSA studies
Wen-Ting Chu et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2013)
Identification of Novel HIV-1 Integrase Inhibitors Using Shape-Based Screening, QSAR, and Docking Approach
Pawan Gupta et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2012)
Classification of Active and Weakly Active ST Inhibitors of HIV-1 Integrase Using a Support Vector Machine
Aixia Yan et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2012)
Molecular Docking: A Powerful Approach for Structure-Based Drug Discovery
Xuan-Yu Meng et al.
Current Computer-Aided Drug Design (2012)
The Activity of the Integrase Inhibitor Dolutegravir Against HIV-1 Variants Isolated From Raltegravir-Treated Adults
Mark R. Underwood et al.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2012)
Routine Access to Millisecond Time Scale Events with Accelerated Molecular Dynamics
Levi C. T. Pierce et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2012)
MMPBSA.py: An Efficient Program for End-State Free Energy Calculations
Bill R. Miller et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2012)
Probing chelation motifs in HIV integrase inhibitors
Arpita Agrawal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes
Kendra E. Hightower et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
K*: A heuristic search algorithm for finding the k shortest paths
Husain Aljazzar et al.
ARTIFICIAL INTELLIGENCE (2011)
LigPlot+: Multiple Ligand-Protein Interaction Diagrams for Drug Discovery
Roman A. Laskowski et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
Investigating the Role of Metal Chelation in HIV-1 Integrase Strand Transfer Inhibitors
Alessia Bacchi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Studying functional dynamics in bio-molecules using accelerated molecular dynamics
Phineus R. L. Markwick et al.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2011)
QSAR study of carboxylic acid derivatives as HIV-1 Integrase inhibitors
Zhengjun Cheng et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Best Practices for QSAR Model Development, Validation, and Exploitation
Alexander Tropsha
MOLECULAR INFORMATICS (2010)
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance
Stephen Hare et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
HIV entry in macrophages is dependent on intact lipid rafts
Gemma C. Carter et al.
VIROLOGY (2009)
RALTEGRAVIR: MOLECULAR BASIS OF ITS MECHANISM OF ACTION
Jean-Francois Mouscadet et al.
EUROPEAN JOURNAL OF MEDICAL RESEARCH (2009)
Integrase and integration: biochemical activities of HIV-1 integrase
Olivier Delelis et al.
RETROVIROLOGY (2008)
y-Randomization and its variants in QSPR/QSAR
Christoph Ruecker et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2007)
Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors
Xingnan Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
History of HAART - the true story of how effective multi-drug therapy was developed for treatment of HIV disease
Martin Delaney
RETROVIROLOGY (2006)
Statins inhibit HIV-1 infection by down-regulating Rho activity
G del Real et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Statin compounds reduce human immunodeficiency virus type 1 replication by preventing the interaction between virion-associated host intercellular adhesion molecule 1 and its natural cell surface ligand LFA-1
JF Giguère et al.
JOURNAL OF VIROLOGY (2004)
Random forest: A classification and regression tool for compound classification and QSAR modeling
V Svetnik et al.
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES (2003)
Metal-dependent inhibition of HIV-1 integrase
N Neamati et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Plasma membrane rafts play a critical role in HIV-1 assembly and release
A Ono et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)