期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
卷 110, 期 5, 页码 1120-1130出版社
WILEY
DOI: 10.1002/jbm.b.34986
关键词
activated carbon fiber cloth; biomimetic carbonated calcium-deficient hydroxyapatite; bone healing; guided bone regeneration; patches
资金
- Region Centre-Val de Loire [FEDER -EX010095, APR-IA 2019-00134921]
The study demonstrates that ACC and ACC/CDA are highly biocompatible in vivo and that ACC/CDA patches can accelerate bone reconstruction by guiding ACC fibers and promoting osteogenesis through the CDA phase. This approach may represent a valuable strategy to accelerate bone regeneration in humans.
We have previously shown that activated carbon fiber cloth (ACC) either uncoated or coated with carbonated calcium-deficient hydroxyapatite (CDA), namely ACC and ACC/CDA, were biocompatible in vitro with human osteoblasts. Here we hypothesized that ACC and ACC/CDA could be used as tissue patches in vivo to accelerate wounded bone healing. In a model of rat femoral defect, we have compared spontaneous cortical bone regeneration with regeneration in the presence of ACC and ACC/CDA patches. At Day 7, 14, and 21, bone formation was evaluated using microcomputed tomography, magnetic resonance imaging, and histological analysis. Our results demonstrate first that these ACC tissues are highly biocompatible in vivo, and second that ACC/CDA patches apposition results in the acceleration of bone reconstruction due to a guiding action of the ACC fibers and an osteogenic effect of the CDA phase. We guess that this approach may represent a valuable strategy to accelerate bone regeneration in human.
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