期刊
JOURNAL OF BIOMECHANICS
卷 127, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2021.110692
关键词
Thrombus; Hemodynamics; Transport; Microstructure; Thrombolysis
资金
- National Science Foundation, United States of America [ACI-1532235, ACI-1532236]
- University of Colorado Boulder, United States of America
- Colorado State University, United States of America
This study develops a microstructure aware model for species transport within and around a macroscale thrombus, using a custom preconditioned fictitious domain formulation for thrombus-hemodynamics interactions. The research demonstrates the formation of coherent flow structures around the thrombus and characterizes species transport from bulk flow to the thrombus boundary.
Flow-mediated transport of biochemical species is central to thrombotic phenomena. Comprehensive three-dimensional modeling of flow-mediated transport around realistic macroscale thrombi poses challenges owing to their arbitrary heterogeneous microstructure. Here, we develop a microstructure aware model for species transport within and around a macroscale thrombus by devising a custom preconditioned fictitious domain formulation for thrombus-hemodynamics interactions, and coupling it with a fictitious domain advection- diffusion formulation for transport. Microstructural heterogeneities are accounted through a hybrid discrete particle-continuum approach for the thrombus interior. We present systematic numerical investigations on unsteady arterial flow within and around a three-dimensional macroscale thrombus; demonstrate the formation of coherent flow structures around the thrombus which organize advective transport; illustrate the role of the permeation processes at the thrombus boundary and subsequent intra-thrombus transport; and characterize species transport from bulk flow to the thrombus boundary and vice versa.
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