期刊
JOURNAL OF BIOMATERIALS APPLICATIONS
卷 36, 期 8, 页码 1444-1457出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/08853282211053923
关键词
Nanostructured-lipid carriers; resveratrol; chitosan hydrogel beads; stability; permeability
资金
- Science and Technology Achievements Transformation Projects of Jiangsu Province of China [BA2014096]
This study developed nanostructured-lipid carriers encapsulated by Chitosan hydrogel beads for efficient topical delivery. The results showed that Chitosan hydrogel beads significantly improved the physical stability of the carriers and promoted drug release and skin permeation.
The aim of this study was to develop nanostructured-lipid carriers (NLC) encapsulated by Chitosan hydrogel beads for the efficient topical carrier. Dynamic light scattering (DLS), X-ray diffraction (XRD), Differential scanning calorimetry (DSC), and attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) were conducted to study the influence of the encapsulation on the characteristic of resveratrol-loaded NLC, and the results showed that there was no impact on resveratrol-loaded NLC. Chitosan hydrogel beads could significantly improve the physical stability of resveratrol-loaded NLC. In vitro release study revealed that resveratrol-loaded NLC-Chitosan hydrogel beads had a more significant sustained-release effect on resveratrol. In vitro transdermal studies suggested that the skin permeation of resveratrol was promoted by the effect of Chitosan hydrogel beads and increased resveratrol distribution in the skin. In vitro cytotoxicity showed that resveratrol-loaded NLC-Chitosan hydrogel beads did not exert a hazardous effect on L929 cells. Hence, NLC-Chitosan hydrogel beads might be a promising method for topical applications of resveratrol.
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