Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses

Article Multidisciplinary Sciences

Spike mutation D614G alters SARS-CoV-2 fitness

Jessica A. Plante et al.

Summary: The D614G substitution in the SARS-CoV-2 spike protein enhances viral replication and infectivity in human lung epithelial cells, primary airway tissues, and hamsters. This variant may increase transmission in the upper respiratory tract and doesn't seem to significantly reduce vaccine efficacy. Further research on therapeutic antibodies targeting the circulating G614 virus is recommended.

NATURE (2021)

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Article Microbiology

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite

Gabriele Cerutti et al.

Summary: Structural analysis revealed that seven potent NTD-directed neutralizing antibodies target a common surface on NTD, forming a single supersite different from the recognition pattern of RBD-directed antibodies.

CELL HOST & MICROBE (2021)

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Article Biochemistry & Molecular Biology

Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum

Chang Liu et al.

Summary: Recent study examined the neutralizing ability of monoclonal antibodies, convalescent and vaccine sera against the Indian variants B.1.617.1 and B.1.617.2, showing that the neutralization of these variants is reduced compared to the ancestral strains, without widespread antibody escape as seen in other variants like B.1.351.

CELL (2021)

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News Item Multidisciplinary Sciences

HOW THE CORONAVIRUS INFECTS OUR CELLS

Megan Scudellari

NATURE (2021)

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Article Biochemistry & Molecular Biology

Evolution, correlation, structural impact and dynamics of emerging SARS-CoV-2 variants

Austin N. Spratt et al.

Summary: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infections are still unmanageable in some parts of the world, with four variants showing increased infectiousness. Structural analysis reveals that the new variants emerged against a background of known mutations.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

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Article Biochemistry & Molecular Biology