Antimicrobial mexicanolide limonoids from the seeds of Khaya senegalensis

Three new mexicanolide limonoids were obtained from the 90% ethanol extract of the seeds of Khaya senegalensis. Their structures were elucidated as senegalenines A-C (1-3) by analysing their 1D/2D NMR and MS spectroscopic analysis. In addition, the isolated limonoids were tested in vitro for antimicrobial potentials against 5 pathogenic microorganisms. Consequently, compounds 1-3 exhibited antimicrobial activity against the tested Gram negative bacteria at the minimum inhibitory concentration values less than 40 mu g/ml.

Automated summary

Three new mexicanolide limonoids were isolated from the seeds of Khaya senegalensis, with structures elucidated through spectroscopic analysis. In vitro testing showed that compounds 1-3 exhibited antimicrobial activity against Gram negative bacteria, particularly at concentrations below 40 mu g/ml.