Two new triterpenoids from the fruits of Aphanamixis polystachya

Two new triucallane triterpenoids, polystanin F (1) and polystanin G (2), along with eight known compounds (3-10) were isolated from the fruits of Aphanamixis polystachya. Their structures were established on the basis of extensive spectroscopic analysis. Moreover, eight compounds were evaluated for their in vitro cytotoxicity against three cancer cell lines (liver cancer RT112, colon cancer HCT-116 and breast cancer M231) using the MTT method. Compound 7 showed significant cytotoxic activity against HCT-116 with IC50 1.27 mu M.

Automated summary

Two new triucallane triterpenoids, polystanin F (1) and polystanin G (2), were isolated from the fruits of Aphanamixis polystachya, along with eight known compounds (3-10). The structures of these compounds were determined through extensive spectroscopic analysis. Furthermore, compound 7 exhibited significant cytotoxic activity against colon cancer HCT-116 cells with an IC50 of 1.27 μM after evaluation for their cytotoxicity against three cancer cell lines using the MTT method.