期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 24, 期 1, 页码 76-87出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2021.2016715
关键词
Jolkinolide B; renal fibrosis; inflammation; epithelial-mesenchymal transition; TGF-beta 1
资金
- National Natural Science Foundation of China [82104483, 81872761, 81960633, 81773958]
- Open project of the State Key Laboratory of Natural Medicine Active Substances and Functions [GTZK202001]
- G20 Engineering Innovation Research Project of Beijing Municipal Science & Technology Commission [Z181100002218029]
- Elite Medical Professionals Open Project of China-Japan Friendship Hospital [ZRJY2021-BJ06, ZRJY2021-TD06]
The study demonstrates that Jolkinolide B can reduce renal fibrosis by inhibiting inflammation through the NF-κB pathway and reversing epithelial-mesenchymal transition mediated by the TGF-β1/Smad pathway.
Renal fibrosis is a critical pathological process lead to a progressive loss of renal function. Jolkinolide B (JB) is a natural compound with anti-inflammatory activity from Euphorbia fischeriana Steud. The study evaluated the effect of JB on renal fibrosis in mice with unilateral ureteral obstruction (UUO). The results showed that JB could decrease renal fibrotic area, reduce phosphorylation of NF-kappa B p65 and the release of TNF-alpha, IL-6 and IL-1 beta, restore the expression of vementin, alpha-SMA and E-cadherin, as well as TGF-beta 1 and p-smad2/3. In conclusion, JB might reduce renal fibrosis by inhibiting inflammation induced by NF-kappa B pathway and EMT mediated by TGF-beta 1/Smad pathway. [GRAPHICS] .
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据