期刊
JOURNAL OF APPLIED GENETICS
卷 63, 期 2, 页码 389-400出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13353-022-00685-0
关键词
Accuracy; Beef cattle; Genomic selection; Inflation; Minor allele frequency; SNP arrays
资金
- Programa Estudantes Convenio de Pos-Graduacao da Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (PECPG-CAPES) [32/2017]
- National Association of Breeders and Researchers (ANCP)
- Programa Escala de Estudiantes de Pos-Graduacao of Asociacion de Universidades GRUPO MONTEVIDEO (PEEPg/AUGM-2019)
- Universidade Estadual Paulista, Faculdade de Ciencias Agrarias e Veterinarias (FCAV/Unesp)
- Universidad de la Republica, Facultad de Veterinaria (UdelaR), Departamento de Genetica y Mejoramiento Animal
- Instituto Nacional de Investigacion Agropecuaria of Uruguay (INIA)
This study investigated the prediction ability for growth and maternal traits using different low-density customized SNP arrays. The results showed that the array density was positively correlated with prediction ability, and customized arrays with more than 10,000 SNPs obtained accurate and less biased predictions.
This study aimed to investigate the prediction ability for growth and maternal traits using different low-density customized SNP arrays selected by informativeness and distribution of markers across the genome employing single-step genomic BLUP (ssGBLUP). Phenotypic records for adjusted weight at 210 and 450 days of age were utilized. A total of 945 animals were genotyped with high-density chip, and 267 individuals born after 2008 were selected as validation population. We evaluated 11 scenarios using five customized density arrays (40 k, 20 k, 10 k, 5 k and 2 k) and the HD array was used as desirable scenario. The GEBV predictions and BIF (Beef Improvement Federation) accuracy were obtained with BLUPF90 family programs. Linear regression was used to evaluate the prediction ability, inflation, and bias of GEBV of each customized array. An overestimation of partial GEBVs in contrast with complete GEBVs and increase of BIF accuracy with the density arrays diminished were observed. For all traits, the prediction ability was higher as the array density increased and it was similar with customized arrays higher than 10 k SNPs. Level of inflation was lower as the density array increased of and was higher for MW210 effect. The bias was susceptible to overestimation of GEBVs when the density customized arrays decreased. These results revealed that the BIF accuracy is sensible to overestimation using low-density customized arrays while the prediction ability with least 10,000 informative SNPs obtained from the Illumina BovineHD BeadChip shows accurate and less biased predictions. Low-density customized arrays under ssGBLUP method could be feasible and cost-effective in genomic selection.
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