期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 77, 期 4, 页码 944-951出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/dkab471
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- University Paris-Saclay, France
This study genetically characterized VIM-producing Enterobacter cloacae complex (ECC) isolates recovered in France from 2015 to 2018. The prevalence of ECC among VIM-producing Enterobacterales increased significantly during this period. Various species and sequence types were identified among these isolates. Additionally, different integrons carrying specific bla(VIM) variants were identified.
Objectives To genetically characterize VIM-producing Enterobacter cloacae complex (ECC) isolates recovered in France from 2015 to 2018. Methods WGS, species determination, MLST, clonal relationship and genetic characterization were performed on 149 VIM-producing ECC isolates. Results Among VIM-producing Enterobacterales, the prevalence of ECC increased drastically from 6% in 2012 to 52% in 2018. The most prevalent species were Enterobacter hormaechei subsp. hoffmannii (40.9%), E. hormaechei subsp. steigerwaltii (21.5%), E. hormaechei subsp. xiangfangensis (14.8%) and ECC clade S (17.4%). Major STs were ST-873 (17.5%), ST-66 (12.1%), ST-78 (9.4%), ST-419 (8.1%), ST-145 (4.7%), ST-50 (4.0%), ST-118 (4.0%) and ST-168 (4.0%). Finally, six different integrons were identified, with some being specific to a given bla(VIM) variant (In916 with bla(VIM-1)-aacA4 '-aphA15-aadA1-catB2 and In416 with bla(VIM-4)-aacA7-dfrA1b-aadA1b-smr2 genes). Conclusions This study demonstrated the genetic diversity among VIM-producing ECC isolates, indicating that their spread is not linked to a single clone.
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