期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 85, 期 2, 页码 851-862出版社
IOS PRESS
DOI: 10.3233/JAD-215187
关键词
Alzheimer disease; amyloid; cerebrospinal fluid; glymphatic system; hydrocephalus; white matter
资金
- Japan Society for the Promotion of Science (JSPS) [JP26461266, JP19K07965]
- Japan Agency for Medical Research and Development (AMED) [16dk0207021h 0001]
- AMED [JP21dm0207073, JP21dk0207057]
This study compared the extent and distribution of white matter lesions (WMLs) between idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD), and found that deep WML volume was significantly larger in iNPH than in AD, while periventricular WML volume was dominant in AD. The lateral ventricular volume positively correlated with WML volume in all participants, and there was a significant negative correlation between lateral ventricular volume and Aβ(38) in iNPH.
Background: Idiopathic normal pressure hydrocephalus (iNPH) is often misdiagnosed as Alzheimer's disease (AD) due to overlapping pathophysiology and similar imaging characteristics, including ventricular enlargement and increased white matter lesions (WMLs). Objective: To compare the extent and distribution of WMLs directly between iNPH and AD and examine the association with underlying pathophysiology. Methods: Twelve patients with iNPH (mean age: 78.08 years; 5 females), 20 with AD (mean age: 75.40 years; 13 females), and 10 normal cognition (NC) participants (mean age: 76.60 years; 7 females) were recruited. The extent and distribution of WMLs and the lateral ventricular volume (LV-V) were evaluated on MRI using voxel-based morphometry analysis. Concentrations of cerebrospinal fluid biomarkers, such as amyloid-beta protein (A beta)(42), A beta(40), A beta(38), and tau species, were also measured. Risk factors for small vessel disease (SVD) were assessed by blood examination and medical records. Results: The periventricular WML volume (PWML-V) and deep WML volume (DWML-V) were significantly larger in iNPH than in AD and NC. The DWML-V was dominant in iNPH, while the PWML-V was dominant in AD and NC. GM-V was significantly smaller in AD than in iNPH and NC. The LV-V positively correlated with WML-V in all participants. There was a significant negative correlation between LV-V and A beta(38) in iNPH. Furthermore, there was no significant difference in SVD risk factors between the groups. Conclusion: The differences in the extent and distribution of WMLs between iNPH and AD, especially predominance of DWML-V over PWML-V in iNPH, may reflect decreased fluid and A beta clearance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据