期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 149, 期 2, 页码 455-465出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2021.12.765
关键词
Severe asthma; endotypes; airway remodeling; steroid resistance; obesity; therapeutics
资金
- Strauss Foundation-McGill University of Montreal, Quebec, Canada
- Research Institute of Medical and Health Sciences, University of Sharjah
- Mohammed bin Rashid University of Medicine and Health Sciences
Severe asthma is an immunopathogenic heterogeneous disease, and studying different endotypes and mechanistic pathways can provide better understanding of its pathogenesis.
Severe asthma is a heterogeneous disease encompassing different phenotypes and endotypes. Although patients with severe asthma constitute a small proportion of the total population with asthma, they largely account for the morbidity and mortality associated with asthma, indicating a clear unmet need. Being distinct from mild and moderate disease, new insights into the immunopathogenesis of severe asthma are needed. The disease endotypes have provided better insights into the immunopathogenic mechanisms underlying severe asthma. Current stratified approach of treating severe asthma based on phenotypes is met with shortcomings, necessitating unbiased multidimensional endotyping to cope with disease complexity. Therefore, in this review, we explore the distinct endotypes and their mechanistic pathways that characterize the heterogeneity observed in severe asthma.
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