4.7 Article

Health Effects of Dietary Oxidized Milk Administration in Offspring Mice during Pregnancy and Lactation with Metabolomic Strategies

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Oxidized Milk Induces Spatial Learning and Memory Impairment by Altering Gut Microbiota in Offspring Mice during Pregnancy and Lactation

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Summary: The study found that oxidized milk affected the gut microbiota in mice, leading to a decrease in mucin-degrading bacteria such as Akkermansia and Lactobacillus and an increase in pro-inflammatory bacteria including Shigella, Mucispirillum, Ruminococcus, Escherichia, and Desulfovibrio. This resulted in increased inflammation in mice, along with upregulation of relevant genes and downregulation of genes and proteins associated with learning and memory ability, ultimately causing impairment in offspring. The findings suggest that oxidative damage in milk is a risk factor for impaired transgenerational learning and memory ability, influenced by gut microbiota and intestinal mucosa conditions.

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