期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 69, 期 40, 页码 11900-11911出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c04626
关键词
theabrownin; thermogenesis; brown adipose tissue; short-chain fatty acids
资金
- National Natural Science Foundation of China [31871752, 32072175]
- Key Research and Development Plan in Shaanxi Province [2020ZDLSF01-07]
- Fundamental Research Funds for the Central Universities of Shaanxi Normal University [GK2020-1601021041]
- Development Program for Innovative Research Team of Shaanxi Normal University [GK202101006]
- Sci-Tech Innovation Team of Shaanxi Province, China [2019TD-035]
The study indicates that theabrownin can enhance BAT activity and promote WAT browning by activating the AMPK-PGC la pathway and modulating SCFAs, thereby improving inflammatory disorder in HFD-fed mice.
This study explored whether the antiobesity effect of theabrownin (TB) extracted from Fu brick tea (FBT) was associated with the activation of brown adipose tissue (BAT) or browning of the white adipose tissue (WAT) in mice fed a high-fat diet (HFD). Mice were divided into five groups, which received a normal diet, HFD, or HFD plus TB (200, 400, and 800 mg/kg), respectively. A 12-week administration of TB in a dose-dependent manner reduced the body weight and WAT weight and improved lipid and glucose disorders in the HFD-fed mice (p < 0.05). TB also promoted the expression of thermogenic and mitochondrial genes, whereas inflammation genes were reduced in interscapular BAT (iBAT), inguinal WAT (MAT), and epididymis white adipose tissue (eWAT), accompanied by improvement in the intestinal homeostasis by improving SCFAs, especially butyric acid levels (p < 0.05), which was related to thermogenic and inflammatory factors of iBAT and iWAT. Mechanistically, TB was shown to efficiently promote thermogenesis by stimulating the AMPK-PGC la pathway with an increase in uncoupling protein 1 (UCP1). Conclusively, these findings suggest that long-term consumption of TB can enhance BAT activity and WAT browning by activating the AMPK-PGC la pathway and modulating SCFAs; meanwhile, SCFAs regulating TB improved inflammatory disorder in HFD-fed mice.
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