期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 69, 期 46, 页码 13925-13932出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c05261
关键词
lutein; nanoemulsion; supplements; excipient emulsion; bioaccessibility
资金
- Natural Science Foundation of Shandong Province [ZR2020QC218]
- Qingdao Municipal Science and Technology Benefit People Project [20-3-4-34-nsh]
- National Science Foundation of China [31801484]
The bioaccessibility of lutein is significantly increased when consumed with excipient nanoemulsions, compared to when consumed alone in capsules or soft gels. Lutein-loaded nanoemulsions exhibit the highest bioaccessibility, attributed to the rapid release and solubilization of lutein within the small intestine. These findings provide important insights for designing more effective lutein supplements.
The impact of lutein-loaded nanoemulsions and excipient nanoemulsions mixed with lutein-based dietary supplements (capsules and soft gels) on the bioaccessibility of lutein was explored using a simulated gastrointestinal tract (GIT). The particle size, particle size distribution, zeta-potential, microstructure, lipid digestibility, and lutein bioaccessibility of all the samples were measured after they were exposed to different environments (stomach and small intestine environments) within a simulated GIT. As expected, the bioaccessibility of lutein from the capsules (1.5%) and soft gels (3.2%) was relatively low when they were administered alone. However, the co-administration of excipient nanoemulsions significantly increased the bioaccessibility of lutein from both the capsules (35.2%) and soft gels (28.7%). This phenomenon was attributed to the fast digestion of the small oil droplets in the excipient nanoemulsions and the further formation of mixed micelles to solubilize any lutein molecules released from the supplements. The lutein-loaded nanoemulsions exhibited a much higher lutein bioaccessibility (86.8%) than any of the supplements, which was attributed to the rapid release and solubilization of lutein when the lipid droplets were rapidly and extensively digested within the small intestine. This study indicates that the bioaccessibility of lutein is much higher in nanoemulsion droplets than that in dietary supplements. However, consuming dietary supplements in the presence of nanoemulsion droplets can greatly increase lutein bioavailability. The results of this study have important guiding significance for the design of more effective lutein supplements.
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