期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 70, 期 4, 页码 1316-1326出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c07432
关键词
tyrosol acyl esters; gastrointestinal distribution; microbial hydrolysis; mice; orally infected; Lactobacillus
资金
- National Natural Science Foundation of China [31901704]
- Scientific Research Project of the Education Department in Liaoning Province [J2020100]
The study on tyrosol acyl esters in mice showed that they were stable in the stomach, had sustained release in the small intestine, and were hydrolyzed by Lactobacillus in the cecum and colon into free tyrosol and fatty acids.
Phenolipids, which have been widely used as food antioxidants, are also a potential functional ingredient. However, their characteristics of gastrointestinal distribution and microbial hydrolysis remain unexplored. In this study, an in vivo mouse model and an in vitro anaerobic fermentation model were used to evaluate the above characteristics of tyrosol acyl esters (TYr-Es) with fatty acids (FAs) of C12:0, C18:0, and C18:2. HPLC-UV measurements indicated that oral TYr-Es were remarkably stable in the stomach environment of mice. However, TYr-Es were hydrolyzed to free TYr by lipase in the small intestine, which showed a sustained-release behavior. Specially, TYr was rapidly and almost completely absorbed in the small intestine. By contrast, detectable amounts of TYr-Es were found in the cecum and colon and could be further hydrolyzed to free TYr and FAs by Lactobacillus. These TYr and FAs can participate in regulating the composition of the intestinal microorganisms, which may lead to some health benefits.
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