Hydroxytyrosol Alleviates Dextran Sulfate Sodium-Induced Colitis by Modulating Inflammatory Responses, Intestinal Barrier, and Microbiome

Article Oncology

IL-1β is a key inflammatory cytokine that weakens lactation-specific tight junctions of mammary epithelial cells

Ken Kobayashi et al.

Summary: This study found that IL-1 beta disrupts TJs between MECs by activating the p38 signaling pathway, leading to decreased levels of CLDN3, CLDN4, and OCLN and a weakened TJ barrier.

EXPERIMENTAL CELL RESEARCH (2021)

添加到收藏夹

Review Immunology

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

Wenjing Yang et al.

Summary: The gut microbiota and microbiota-derived metabolites play a critical role in maintaining immune homeostasis and are involved in the pathogenesis of various immune-related inflammatory disorders.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

添加到收藏夹

Article Agriculture, Multidisciplinary

Potential Mechanisms Mediating the Protective Effects of Tricholoma matsutake-Derived Peptides in Mitigating DSS-Induced Colitis

Mengqi Li et al.

Summary: The study demonstrated that peptides derived from Tricholoma matsutake alleviate colitis symptoms by regulating TJ protein expression and suppressing pro-inflammatory cytokine production.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

添加到收藏夹

Review Nutrition & Dietetics

Short-Chain Fatty Acids, Maternal Microbiota and Metabolism in Pregnancy

Maciej Zietek et al.

Summary: This study summarizes the potential impact and mechanisms of SCFAs on maternal metabolism during pregnancy, emphasizing their crucial role in maternal health and neonatal development. Additionally, it also discusses the mechanisms of SCFAs as signaling molecules regulating the body's energy balance through G-protein receptors.

NUTRIENTS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Natural-Derived Polysaccharides From Plants, Mushrooms, and Seaweeds for the Treatment of Inflammatory Bowel Disease

Cailan Li et al.

Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease affecting the gastrointestinal tract, with treatment options mainly including drugs and surgery. However, the long-term use of drugs can result in serious side effects for IBD patients, prompting the need for the development of effective and safe treatment options. Natural-derived polysaccharides have gained attention for their therapeutic effects on IBD, showing promising potential for application in IBD therapy.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism

Ciliang Guo et al.

Summary: This study found that the polysaccharide HAW1-2 from hawthorn can alleviate colitis in mice by regulating inflammatory cytokines and inhibiting related molecular pathways. Additionally, HAW1-2 can modify the composition of gut microbiota, promoting the proliferation of beneficial bacteria and generating beneficial short-chain fatty acids to inhibit colitis.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

添加到收藏夹

Article Agriculture, Multidisciplinary

Dietary Tangeretin Alleviated Dextran Sulfate Sodium-Induced Colitis in Mice via Inhibiting Inflammatory Response, Restoring Intestinal Barrier Function, and Modulating Gut Microbiota

Bin Chen et al.

Summary: The study demonstrated that TAN significantly alleviated DSS-induced colitis by regulating inflammation, promoting intestinal barrier function restoration, improving gut microbiota, and enhancing short-chain fatty acids production.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

添加到收藏夹

Article Immunology

Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C

Vishwas Mishra et al.

Summary: Activation mutations in receptor guanylyl cyclase C (GC-C) lead to early-onset diarrhea and chronic inflammatory bowel disease. A new mouse model with an activating mutation in Gucy2c showed increased intestinal cGMP levels and susceptibility to colitis, providing insights into the role of cGMP in gut inflammation.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

添加到收藏夹

Article Microbiology

Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis

Zhenhua Wu et al.

Summary: The study found that oral EGCG helps alleviate colonic inflammation by increasing the abundance of Akkermansia, a short-chain fatty acids-producing bacteria, and promoting SCFAs production. Prophylactic supplementation of EGCG also showed beneficial outcomes. FMT experiments confirmed the role of EGCG in attenuating colitis.

MICROBIOME (2021)

添加到收藏夹

Review Pediatrics

Splenomegaly in Children and Adolescents

Meinolf Suttorp et al.

Summary: The spleen, as the largest organ in the immune system, plays a crucial role in filtering microorganisms and blood cells, as well as initiating immune responses. Diagnosing splenomegaly in children and adolescents requires age-specific size references and consideration of various potential causes.

FRONTIERS IN PEDIATRICS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties

Monica Bucciantini et al.

Summary: Oxidative stress and inflammation are major causes of chronic diseases, leading to the search for new active substances without side effects. Plant-derived compounds offer potential as anti-inflammatory and antioxidant molecules, with natural products being structurally optimized by evolution for specific biological functions. Extensive studies have shown the therapeutic effects of polyphenols from extra virgin olive oil against various chronic diseases, highlighting their role in inhibiting molecular signaling pathways activated by oxidative stress.

ANTIOXIDANTS (2021)

添加到收藏夹

Article Infectious Diseases

Core Altered Microorganisms in Colitis Mouse Model: A Comprehensive Time-Point and Fecal Microbiota Transplantation Analysis

Lijun Shang et al.

Summary: Inflammatory bowel disease (IBD) is characterized by chronic and relapsing inflammation within the gastrointestinal tract, and antibiotics have been used for treatment but with adverse effects. Host microbiome is implicated in the pathogenesis of IBD, and modifying the bacterial population may improve antibiotic therapy effectiveness.

ANTIBIOTICS-BASEL (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Adherence to a Mediterranean diet is associated with a lower risk of later-onset Crohn's disease: results from two large prospective cohort studies

Hamed Khalili et al.

GUT (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Hydroxytyrosol: A natural compound with promising pharmacological activities

Matteo Bertelli et al.

JOURNAL OF BIOTECHNOLOGY (2020)

添加到收藏夹

Article Chemistry, Medicinal

GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis

Simona De Marino et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Association of colitis with gut-microbiota dysbiosis in clathrin adapter AP-1B knockout mice

Aditi Jangid et al.

PLOS ONE (2020)

添加到收藏夹

Review Nutrition & Dietetics

Nutrition, IBD and Gut Microbiota: A Review

Maria Chiara Mentella et al.

NUTRIENTS (2020)

添加到收藏夹

Review Nutrition & Dietetics

Dietary Fiber, Gut Microbiota, and Metabolic Regulation-Current Status in Human Randomized Trials

Mari C. W. Myhrstad et al.

NUTRIENTS (2020)

添加到收藏夹

Review Physiology

Targeting Myeloperoxidase (MPO) Mediated Oxidative Stress and Inflammation for Reducing Brain Ischemia Injury: Potential Application of Natural Compounds

Shuang Chen et al.

FRONTIERS IN PHYSIOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mediterranean Diet: Lipids, Inflammation, and Malaria Infection

Adriana R. Silva et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Agriculture, Multidisciplinary

Anti-Inflammatory and Intestinal Microbiota Modulation Properties of Jinxiang Garlic (Allium sativum L.) Polysaccharides toward Dextran Sodium Sulfate-Induced Colitis

Xin Shao et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Nigella A ameliorates inflammation and intestinal flora imbalance in DSS induced colitis mice

Xingjiang Hu et al.

AMB EXPRESS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

A critical role of endothelial cell protein C receptor in the intestinal homeostasis in experimental colitis

Vijay Kondreddy et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Effects of the polysaccharide SPS-3-1 purified from Spirulina on barrier integrity and proliferation of Caco-2 cells

Qun Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

添加到收藏夹

Review Food Science & Technology

Prebiotic effect of dietary polyphenols: A systematic review

Aline Medeiros Alves-Santos et al.

JOURNAL OF FUNCTIONAL FOODS (2020)

添加到收藏夹

Article Oncology

A Mediterranean Diet Mix Has Chemopreventive Effects in a Murine Model of Colorectal Cancer Modulating Apoptosis and the Gut Microbiota

Giulia Piazzi et al.

FRONTIERS IN ONCOLOGY (2019)

添加到收藏夹

Review Microbiology

Probiotic Bacteria: A Promising Tool in Cancer Prevention and Therapy

Agata Gorska et al.

CURRENT MICROBIOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Carcinoembryonic antigen (CEACAM) family members and Inflammatory Bowel Disease

Maebh Kelleher et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide

Matthew T. Henke et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Correction Immunology

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases (vol 10, 277, 2019)

Daniela Parada Venegas et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Oncology

Canmei Formula Reduces Colitis-Associated Colorectal Carcinogenesis in Mice by Modulating the Composition of Gut Microbiota

Huayue Zhang et al.

FRONTIERS IN ONCOLOGY (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence

Filip Vlavcheski et al.

ANTIOXIDANTS (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

Potential Health Benefits of Olive Oil and Plant Polyphenols

Monika Gorzynik-Debicka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Article Immunology

Microbial dysbiosis associated with impaired intestinal Na+/H+ exchange accelerates and exacerbates colitis in ex-germ free mice

Christy A. Harrison et al.

MUCOSAL IMMUNOLOGY (2018)

添加到收藏夹

Review Cell Biology

Therapeutic Potential of Salviae Miltiorrhizae Radix et Rhizoma against Human Diseases Based on Activation of Nrf2-Mediated Antioxidant Defense System: Bioactive Constituents and Mechanism of Action

Guo-Hui Li et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mechanisms regulating intestinal barrier integrity and its pathological implications

Chaithanya Chelakkot et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

添加到收藏夹

Article Ecology

Systems-level metabolism of the altered Schaedler flora, a complete gut microbiota

Matthew B. Biggs et al.

ISME JOURNAL (2017)

添加到收藏夹

Review Gastroenterology & Hepatology

Gut microbiota and IBD: causation or correlation?

Josephine Ni et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

添加到收藏夹

Article Nutrition & Dietetics

Bifidobacterium adolescentis IM38 ameliorates high-fat diet-induced colitis in mice by inhibiting NF-κB activation and lipopolysaccharide production by gut microbiota

Su-Min Lim et al.

NUTRITION RESEARCH (2017)

添加到收藏夹

Article Immunology

Implication of Nrf2/HO-1 pathway in the coloprotective effect of coenzyme Q10 against experimentally induced ulcerative colitis

Ahmed E. Khodir et al.

INFLAMMOPHARMACOLOGY (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

Agnieszka Loboda et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD

Claudio Pirozzi et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2016)

添加到收藏夹

Article Food Science & Technology

Toxicological evaluation of an olive extract, H35: Subchronic toxicity in the rat

Jacqueline Heilman et al.

FOOD AND CHEMICAL TOXICOLOGY (2015)

添加到收藏夹

Article Agriculture, Multidisciplinary

Oleuropein Suppresses LPS-Induced Inflammatory Responses in RAW 264.7 Cell and Zebrafish

Su-Jung Ryu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2015)

添加到收藏夹

Review Immunology

Inflammatory bowel disease: clinical aspects and treatments

Marc Fakhoury et al.

JOURNAL OF INFLAMMATION RESEARCH (2014)

添加到收藏夹

Article Plant Sciences

Oleuropein Protects against Dextran Sodium Sulfate-Induced Chronic Colitis in Mice

Elisa Giner et al.

JOURNAL OF NATURAL PRODUCTS (2013)

添加到收藏夹

Article Nutrition & Dietetics

Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model

Susana Sanchez-Fidalgo et al.

EUROPEAN JOURNAL OF NUTRITION (2012)

添加到收藏夹

Article Microbiology

Desulfovibrio desulfuricans Bacteremia in an Immunocompromised Host with a Liver Graft and Ulcerative Colitis

Isabel Verstreken et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2012)

添加到收藏夹

Article Gastroenterology & Hepatology

Colitis and Intestinal Inflammation in IL10(-/-) Mice Results From IL-13R alpha 2-Mediated Attenuation of IL-13 Activity

Mark S. Wilson et al.

GASTROENTEROLOGY (2011)

添加到收藏夹

Article Cell Biology

Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis

Michael Gersemann et al.

DIFFERENTIATION (2009)

添加到收藏夹

Article Gastroenterology & Hepatology

Isolation of flagellated bacteria implicated in Crohn's disease

L. Wayne Duck et al.

INFLAMMATORY BOWEL DISEASES (2007)

添加到收藏夹

Hydroxytyrosol Alleviates Dextran Sulfate Sodium-Induced Colitis by Modulating Inflammatory Responses, Intestinal Barrier, and Microbiome

相关参考文献

导出引文

分享论文