4.7 Article

Protective Effect of Ginkgolide B against Cognitive Impairment in Mice via Regulation of Gut Microbiota

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Immunology

Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson's disease via gut microbiota-GLP-1 pathway

Jing Sun et al.

Summary: The study suggests that the probiotic Clostridium butyricum (Cb) has neuroprotective effects on Parkinson's disease (PD) by improving abnormal gut microbiota-gut-brain axis. This intervention could potentially reverse motor deficits, dopaminergic neuron loss, synaptic dysfunction, and microglia activation in PD, providing a new insight into treating PD through gut microbiota modulation.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Biochemistry & Molecular Biology

Ginkgolide B protects against cognitive impairment in senescence-accelerated P8 mice by mitigating oxidative stress, inflammation and ferroptosis

Li Shao et al.

Summary: GB improved cognitive dysfunction in senescence-accelerated P8 (SAMP8) mice by attenuating oxidative stress, neuroinflammation, and ferroptosis, which alleviated cognitive defects induced by Alzheimer's disease.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Medicine, Research & Experimental

Ginkgolide B treatment regulated intestinal flora to improve high-fat diet induced atherosclerosis in ApoE-/- mice

Zhiyang Lv et al.

Summary: This study found that the treatment with GB could alleviate dyslipidemia, inflammation, increased atherosclerotic plaque, and gut barrier dysfunction induced by a high fat diet. Moreover, the treatment obviously inhibited the mRNA level and protein expression of FMO3, leading to decreased concentrations of TMA and TMAO, which was related to changes in the gut microbiota of HFD-fed mice. Modulation of gut microbiota, specifically the increased abundance of Bacteroides and decreased abundance of Helicobacter, may contribute to the antiatherosclerotic effects of GB.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Cell Biology

MicroRNA-340-5p increases telomere length by targeting telomere protein POT1 to improve Alzheimer's disease in mice

Xin Li et al.

Summary: The study revealed that miR-340-5p could increase cellular telomere length and delay cell senescence by regulating POT1, thereby improving AD symptoms in mice.

CELL BIOLOGY INTERNATIONAL (2021)

Article Toxicology

Alendronate reduces the cognitive and neurological disturbances induced by combined doses of d-galactose and aluminum chloride in mice

Saima Zameer et al.

Summary: The study demonstrates that alendronate can improve cognitive and neurological disturbances caused by age-related disorders, including neuroinflammation, oxidative stress, and neuronal damage. Experimental findings show that alendronate can effectively reverse these changes.

JOURNAL OF APPLIED TOXICOLOGY (2021)

Article Oncology

Ginkgolide B-induced AMPK pathway activation protects astrocytes by regulating endoplasmic reticulum stress, oxidative stress and energy metabolism induced by Aβ1-42

Jing Wang et al.

Summary: The study found that Ginkgolide B (GB) can alleviate Aβ(1-42)-induced astrocyte apoptosis, inhibit endoplasmic reticulum stress, oxidative stress, energy metabolism disorders, and Aβ(1-42) production by activating the AMPK signaling pathway. This provides a basis for the innovative use of GB as a therapeutic agent for Aβ(1-42)-related Alzheimer's disease.

MOLECULAR MEDICINE REPORTS (2021)

Article Oncology

Immunosuppressive activity is attenuated by Astragalus polysaccharides through remodeling the gut microenvironment in melanoma mice

Guiqing Ding et al.

Summary: The study demonstrates that Astragalus polysaccharides can modulate the immune function in tumor-bearing mice by remodeling the gut microbiota, particularly by reducing the number of myeloid-derived suppressor cells. Results from 16S rRNA analysis show that APS significantly regulates various microorganisms, with changes in abundance related to the increase of metabolites that promote tumor growth.

CANCER SCIENCE (2021)

Article Immunology

Natural antioxidants enhance the power of physical and mental activities versus risk factors inducing progression of Alzheimer's disease in rats

Azza A. Ali et al.

Summary: The study aimed to investigate the potential effects of antioxidants and physical and mental activities in alleviating the risk of Alzheimer's disease progression worsened by social isolation and protein malnutrition. The combination protocol significantly increased brain monoamines, superoxide dismutase activity, and total antioxidant capacity, while mitigating harmful biochemical markers in rat models of AD, social isolation, and protein malnutrition.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Review Neurosciences

Gut Microbiota and Alzheimer's Disease: Pathophysiology and Therapeutic Perspectives

Yanli Li et al.

Summary: As individuals age, gut microbiota diversity decreases and dominant bacteria change, which is closely related to systemic inflammation and health status. Dysbiosis of the gut microbiota is associated with cognitive impairment and neurodegenerative diseases.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Article Oncology

Ginkgolide B-mediated therapeutic effects on perioperative neurocognitive dysfunction are associated with the inhibition of iNOS-mediated production of NO

Ting Luo et al.

Summary: The study demonstrated that GB exerts a protective effect against PND by inhibiting iNOS-induced NO production, increasing SOD levels, and alleviating neuronal loss and apoptosis.

MOLECULAR MEDICINE REPORTS (2021)

Review Geriatrics & Gerontology

Roles and Mechanisms of Gut Microbiota in Patients With Alzheimer's Disease

Shaochang Wu et al.

Summary: Alzheimer's disease is a common age-related progressive neurodegenerative disease linked to dysbiosis of gut microbiota. Alterations in gut microbiota can impact brain function and behavior, influencing the pathogenesis and progression of AD.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Article Pharmacology & Pharmacy

Ginkgolide B Alleviates Learning and Memory Impairment in Rats With Vascular Dementia by Reducing Neuroinflammation via Regulating NF-κB Pathway

Lijuan Huang et al.

Summary: The study found that GB can significantly improve the learning and memory ability of VD rats by reducing TLR4/NF-kappa B mediated neuroinflammation, suggesting that GB may be a potential drug for amelioration of learning and memory impairment in rats with VD.

FRONTIERS IN PHARMACOLOGY (2021)

Article Gastroenterology & Hepatology

The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis

Fan Deng et al.

Summary: Intestinal ischemia/reperfusion (I/R) injury disrupts gut microbiota and causes significant changes in metabolites, while capsiate (CAT), a gut microbiota metabolite, can alleviate ferroptosis-dependent intestinal I/R injury.

GUT MICROBES (2021)

Article Cell Biology

Neuro-amelioration of cinnamaldehyde in aluminum-induced Alzheimer's disease rat model

Hesham N. Mustafa

JOURNAL OF HISTOTECHNOLOGY (2020)

Article Clinical Neurology

Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's

Fanny M. Elahi et al.

ALZHEIMERS & DEMENTIA (2020)

Article Medicine, Research & Experimental

Antioxidative and antiapoptosis: Neuroprotective effects of dauricine in Alzheimer's disease models

Lingfeng Wang et al.

LIFE SCIENCES (2020)

Article Food Science & Technology

Aluminum chloride-induced amyloid β accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin

Kitipong Promyo et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

Article Agriculture, Multidisciplinary

Fructooligosaccharides Ameliorating Cognitive Deficits and Neurodegeneration in APP/PS1 Transgenic Mice through Modulating Gut Microbiota

Jing Sun et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

Article Nutrition & Dietetics

Lactobacillus acidophilus Exerts Neuroprotective Effects in Mice with Traumatic Brain Injury

Yuanyuan Ma et al.

JOURNAL OF NUTRITION (2019)

Article Neurosciences

Gut Microbiota is Altered in Patients with Alzheimer's Disease

Zhen-Qian Zhuang et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Article Agriculture, Multidisciplinary

Clostridium butyricum Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior in Mice via the Gut-Brain Axis

Jing Sun et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

Review Pharmacology & Pharmacy

A Recent Update on the Effects of Omega-3 Fatty Acids in Alzheimer's Disease

Thekkuttuparambil Ananthanarayanan Ajith

CURRENT CLINICAL PHARMACOLOGY (2018)

Article Multidisciplinary Sciences

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

T. Harach et al.

SCIENTIFIC REPORTS (2017)

Review Cell Biology

Role of RAGE in Alzheimer's Disease

Zhiyou Cai et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2016)

Article Immunology

Lactobacillus Species: Taxonomic Complexity and Controversial Susceptibilities

Ellie J. C. Goldstein et al.

CLINICAL INFECTIOUS DISEASES (2015)

Article Cell Biology

Mechanisms of Action of Bcl-2 Family Proteins

Aisha Shamas-Din et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Geriatrics & Gerontology

Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

Christopher C. Rowe et al.

NEUROBIOLOGY OF AGING (2010)

Article Biochemistry & Molecular Biology

RAGE regulates BACE1 and Aβ generation via NFAT1 activation in Alzheimer's disease animal model

H. J. Cho et al.

FASEB JOURNAL (2009)

Article Neurosciences

Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease

Miles C. Miller et al.

BRAIN RESEARCH (2008)

Article Clinical Neurology

RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease

John E. Donahue et al.

ACTA NEUROPATHOLOGICA (2006)

Article Biochemistry & Molecular Biology

RAGE and amyloid beta interactions: Atomic force microscopy and molecular modeling

MO Chaney et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2005)

Article Biochemistry & Molecular Biology

RAGE potentiates Aβ-induced perturbation of neuronal function in transgenic mice

O Arancio et al.

EMBO JOURNAL (2004)

Review Pathology

Mechanisms of apoptosis

JC Reed

AMERICAN JOURNAL OF PATHOLOGY (2000)