期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 70, 期 1, 页码 157-170出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c06475
关键词
sea cucumber peptides; learning and memory; memory impairment; hippocampus; Fourier transform infrared (FTIR) microscopy; fatty acid
资金
- National Key Research and Development Program of China [2017YFD0400500]
The study found that SCP improved behavioral performance and regulated the disorder of the cholinergic system in mouse models in a dose-dependent manner. High-dose SCP repaired damaged neuronal cells, enhanced the Nissl body number, increased the unsaturated lipid level, and activated the long-term potentiation (LTP) pathway in both mouse and rat hippocampus.
Social stress and unhealthy diets lead to memory impairment, triggering health problems. This study aimed to determine the mitigating effect and regulation mechanism of sea cucumber peptides (SCP) against memory impairment. Here, scopolamine-induced memory impairment in mouse and rat models was used based on behavioral tests, a histological staining technique, Fourier transform infrared microscopy, and gas-chromatographic analysis as well as a Western blotting method. SCP improved the behavioral performance and regulated the disorder of the cholinergic system in mouse models in a dose-dependent manner. Therefore, the underlying mechanism was explored in high-dose SCP using mouse and rat models. SCP repaired damaged neuronal cells, enhanced the Nissl body number, increased the unsaturated lipid level, and activated the long-term potentiation (LTP) pathway (p-CaMKII, p-CREB, and BDNF), both in the mouse and rat hippocampus. The results indicated that SCP upregulated the LTP pathway and unsaturated lipid level to combat scopolamine-induced memory impairment, suggesting that SCP was a potential candidate for neurological recovery.
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