期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 70, 期 6, 页码 1878-1889出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c07547
关键词
cocoa; exercise; microbiota; serum metabolome; fecal metabolome
资金
- Ministry of Economy and Competitiveness, Spain [AGL2016-77288-R]
- European Molecular Biology Organization (EMBO) [STF 8131]
- Ministry of Education, Culture and Sports Spain [2016/01110]
- MetaboHUB infrastructure [ANR-11-INBS-0010]
This study investigated the effects of cocoa intake on gastrointestinal symptoms, gut microbiota, and metabolites in endurance athletes during training. The results showed that cocoa had no significant impact on gastrointestinal symptoms or metabolites, but it did alter the abundance of certain gut bacteria genera.
Cocoa is used in the sports world as a supplement, although there is no consensus on its use. We investigated the effect of cocoa intake on intestinal ischemia (intestinal fatty acid-binding protein (I-FABP)), serum lipopolysaccharide (LPS) levels, gastrointestinal symptoms, and gut microbiota in endurance athletes during their training period on an unrestricted diet. We also performed a metabolomics analysis of serum and feces after a bout of exercise before and after supplementation. Cocoa consumption had no effect on I-FABP, LPS, or gastrointestinal symptoms. Cocoa intake significantly increased the abundance of Blautia and Lachnospira genera and decreased the abundance of the Agathobacter genus, which was accompanied by elevated levels of polyphenol fecal metabolites 4-hydroxy-5-(phenyl)-valeric acid and O-methyl-epicatechin-O-glucuronide. Our untargeted approach revealed that cocoa had no significant effects on serum and fecal metabolites and that its consumption had little impact on the metabolome after a bout of physical exercise.
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