期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 70, 期 5, 页码 1640-1651出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c06622
关键词
sodium dodecyl sulfate; soybean lipophilic protein; self-assembly; resveratrol; digestibility
资金
- National Natural Science Foundation of China [32172141]
This study developed a network-like nanostructure using soybean lipophilic protein as a nanocarrier for resveratrol. The nanostructure showed high encapsulation efficiency, water solubility, oxidation resistance, and improved digestibility.
The development of protein-based nanocarriers to improve the water solubility, stability, and bioavailability of hydrophobic or poorly soluble bioactive molecules has attracted increasing interest in the food and pharmaceutical industries. In this study, a network-like nanostructure of soybean lipophilic protein (LP) was obtained through sodium dodecyl sulfate (SDS)-dependent decomposition and recombination. This nanostructure served as an excellent nanocarrier for resveratrol (Res), a poorly soluble biologically active molecule. The structure of LP gradually decomposed into its independent subunits at SDS concentrations <= 5% (w/v). After the removal of SDS, the dissociated subunits partially reassembled into a fibrous network-like nanostructure in which the Res molecules were encapsulated, and they preferentially interacted with the hydrophobic subunits (alpha and alpha' subunits and the 24 kDa subunit) of the protein. This system exhibited a high encapsulation efficiency (95.93%), high water solubility (85.29%), extraordinary oxidation resistance (DPPH radical scavenging activity of 67.1%), and improved Res digestibility (78.7%).
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