Carbonyl Chemistry and the Formation of Heterocyclic Aromatic Amines with the Structure of Aminoimidazoazaarene

Recent studies have shown that the formation of heterocyclic aromatic amines (HAAs) with the structure of aminoimidazoazaarene is produced by reaction of specific reactive carbonyls with ammonia and creatin(in)e. These carbonyl compounds, which are usually the limiting reagents, have multiple origins. Therefore, HAA formation cannot be considered to be produced as a consequence of a single process, such as the Maillard reaction, but of any process that generates the involved reactive carbonyls. In addition, inhibition of HAA formation should be related to the control of these reactive carbonyls: inhibiting their formation, using conditions that limit their reactivity, and promoting their trapping.

Automated summary

Recent studies have shown that the formation of heterocyclic aromatic amines (HAAs) is a result of specific reactive carbonyls reacting with ammonia and creatin(in)e. These carbonyl compounds, which are usually limiting reagents, have multiple origins. Therefore, inhibition of HAA formation should focus on controlling the production of these reactive carbonyls, limiting their reactivity, and promoting their trapping.