Suicidality in patients with premenstrual dysphoric disorder-A systematic review and meta-analysis

Background: Whether premenstrual dysphoric disorder (PMDD) is correlated with the risk of suicidality and the extent of its effect on suicidality are unclear. The present study was conducted to elucidate the association between PMDD and suicidality from relevant studies. Methods: Four electronic databases, namely, Scopus, Embase, PubMed, and Web of Science, were searched from inception to November 15, 2020. Quality assessment, data synthesis, and sensitivity analysis were performed on the included studies. Results: Six studies with 8 532 participants were included in this meta-analysis. PMDD was associated with an increased risk of suicidal ideation (odds ratio [OR]=2.34, 95% confidence interval [CI]=1.50-3.18, I-2=0.0%, p=0.99, k=4). Patients with PMDD had a greater risk of experiencing suicide attempt (OR=2.13, 95% CI=1.05-3.21, I-2=0.0%, p=0.81, k=5). PMDD was associated with an increased risk of suicidal plan (OR=2.24, 95% CI=1.03-3.45, I-2=0.0%, p=0.96, k=2). Limitations: The diagnosis of PMDD should be considered provisional in all the included studies. Conclusions: Among PMDD sufferers there would be a group of particularly suicidal women. Clinicians who treat patients with PMDD should be vigilant for signs of suicidal ideation and behavior to implement better treatment and preventive measures.

Automated summary

The study found that PMDD patients have a higher risk of suicidal ideation, suicide attempt, and suicide plan. Clinicians treating PMDD patients should be vigilant about signs of suicide ideation and behavior to implement better treatment and preventive measures.