期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 293, 期 -, 页码 90-96出版社
ELSEVIER
DOI: 10.1016/j.jad.2021.06.018
关键词
Brain-derived neurotrophic factor; Neurocognitive performance; Bipolar disorder; Major depressive disorder
资金
- National Natural Sci-ence Foundation of China [81971258, 81270019, 81501163, 81901401]
The study found significantly lower BDNF levels in patients with Bipolar Type II disorder (BD II) compared to patients with Major Depressive Disorder (MDD) and healthy controls. BD II and MDD patients showed similar cognitive deficits in attention, delayed memory, and RBANS total score. BDNF levels were positively associated with visuospatial/constructional and Stroop color-word in the BD II group, and with language in the MDD group.
Objective: This study aimed to investigate the role of Brain-derived neurotrophic factor (BDNF) in clinical and cognitive outcomes in medication-naive patients with Bipolar type II disorder (BD II) and Major depressive disorder (MDD). Methods: 45 outpatients with BD II, 40 outpatients with MDD and 40 healthy controls (HCs) were recruited, and sociodemographic and clinical data were collected. Their BDNF serum levels were measured and analyzed with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Results: BDNF levels were significantly lower in BD II patients than in MDD patients and HCs (p = 0.001). BD II and MDD patients had similar cognitive performance deficits shown on Attention (p = 0.001), Delayed memory (p = 0.001), and RBANS total score (p = 0.001). BDNF levels were positively associated with Visuospatial / constructional and Stroop color-word in BD II group, and with language in MDD group. The area under the curve (AUC) of the ROC analysis in BD II vs. MDD was 0.664, therefore, BDNF levels could not distinguish BD II from MDD. Conclusion: Our study showed the decreased serum BDNF in MDD and BD II patients, suggesting BDNF may be involved in the pathophysiology of MDD and BD II. BDNF and cognitive deficits are both of low efficiency in distinguishing BD II from MDD. Decrease of BDNF may potentially indicate cognitive dysfunction in BD II and MDD patients with a current depressive episode.
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