期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 295, 期 -, 页码 873-882出版社
ELSEVIER
DOI: 10.1016/j.jad.2021.08.106
关键词
P300; Depression; Treatment outcome; Behavioral therapy; Event-related potential
资金
- National Institue on Minority Health and Health Disparaties (NIMHD) [K99MD015736]
- National Institute of General Medical Sciences (NIGMS) center grant [P20GM121312]
- NIMH [K23MH108707, R01MH123691]
- National Institute of Drug Abuse [U01DA041089]
- National Institute of Mental Health [F31MH122090]
This study found that blunted neural responses to reward in individuals with Major Depressive Disorder may predict their completion of and response to behavioral therapy. Participants who completed therapy showed better performance in P300 amplitudes.
Introduction: Treatment effectiveness for major depressive disorder (MDD) is often affected by client non-adherence, dropout, and non-response. Identification of client characteristics predicting successful treatment completion and/or response (i.e., symptom reduction) may be an important tool to increase intervention effectiveness. It is unclear whether neural attenuations in reward processing associated with MDD predict behavioral treatment outcome. Methods: This study aimed to determine whether blunted neural responses to reward at baseline differentiate MDD (n = 60; 41 with comorbid anxiety) and healthy control (HC; n = 40) groups; and predict MDD completion of and response to 7-10 sessions of behavior therapy. Participants completed a monetary incentive delay (MID) task. The N200, P300, contingent negative variation (CNV) event related potentials (ERPs) and behavioral responses (reaction time [RT], correct hits) were quantified and extracted for cross-sectional group analyses. ERPs and behavioral responses demonstrating group differences were then used to predict therapy completion and response within MDD. Results: MDD exhibited faster RT and smaller P300 amplitudes than HC across conditions. Within the MDD group, treatment completers (n = 37) exhibited larger P300 amplitudes than non-completers (n = 21). Limitations: : This study comprises secondary analyses of EEG data; thus task parameters are not optimized to examine feedback ERPs from the paradigm. We did not examine heterogenous presentations of MDD; however, severity and comorbidity did not influence findings. Conclusions: Previous studies suggest that P300 is an index of motivational salience and stimulus resource allocation. In sum, individuals who deploy greater neural resources to task demands are more likely to persevere in behavioral therapy.
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