期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 299, 期 -, 页码 67-72出版社
ELSEVIER
DOI: 10.1016/j.jad.2021.11.057
关键词
Depression; Mental health; Muscle weakness; Physical function; Targeted maximum likelihood estimation
资金
- JSPS
- ANR under the Open Research Area for the Social Sciences (ORA program) [JPJSJRP20181403]
- DFG under the Open Research Area for the Social Sciences (ORA program) [JPJSJRP20181403]
- ESRC under the Open Research Area for the Social Sciences (ORA program) [JPJSJRP20181403]
- SSHRC under the Open Research Area for the Social Sciences (ORA program) [JPJSJRP20181403]
This study found that maintaining non-depressive symptoms or improving depressive symptoms can protect older adults with weak handgrip strength, indicating an association between depressive symptoms and muscle strength. The results underscore the importance of managing depressive symptoms to prevent declining physical function.
Background: Few studies have examined the associations between changes in depressive symptoms and handgrip strength in older people. This study aimed to examine the magnitude of the association between depressive symptoms over 2 years and weak handgrip strength on the 4 years of follow-up. Methods: We conducted a longitudinal study using data from the English Longitudinal Study of Aging, a nationally representative panel survey of older adults in England. Data were derived from waves 4 (2008-2009), 5 (2010-2011), and 6 (2012-2013). A total of 5,080 participants were included in the analysis. Depressive symptoms were dichotomized using the eight-item Center for Epidemiological Studies Depression Scale in waves 4 and 5 and were regarded as the exposure. Handgrip strength measurements objectively measured in wave 6 were dichotomized according to the 25th percentile of the British norm and used as the outcome. The targeted maximum likelihood estimation model was utilized to assess time-variant depressive symptoms on handgrip strength, adjusted for time-variant and time-invariant covariates. Results: The maintenance of non-depressive symptoms (relative risk [RR], 0.72; 95% confidence interval [CI], 0.59-0.87) or improvement of depressive symptoms (RR, 0.71; 95% CI, 0.55-0.91) had a protective effect on weak handgrip strength compared with the persistence of depressive symptoms. Limitation: This study is not a randomized control trial but a longitudinal observational study, indicating that our study finding may still have been affected by unknown confounders. Conclusion: Our findings suggest the importance of managing depressive symptoms to prevent poor physical function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据