Adherence to Pre-Exposure Prophylaxis in Adolescents and Young Adults: A Systematic Review and Meta-Analysis

This meta-analysis synthesized the proportion of adolescents and young adults (AYAs) who are adherent to pre-exposure prophylaxis (PrEP) and factors moderating adherence. A systematic search and CINAHL. Included studies reported the proportion of AYAs (mean age < 29 years) who were PrEP evaluated potential moderating variables. A total of 41 individual samples, from 29 studies, of 8,679 defined thresholds for PrEP adherence was .64 (95% confidence interval .57-.71) across studies. Subgroup analyses revealed that adherence was lower in young cisgender women (.46) than young participant age, country, or strategies to promote adherence were found. Across published studies to (c) 2021 Society for Adolescent Health and Medicine. All rights reserved.

Automated summary

This meta-analysis examined adherence to pre-exposure prophylaxis (PrEP) among adolescents and young adults, finding that adherence was lower in young cisgender women compared to other young participants.