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Risk of N-Nitrosodimethylamine (NMDA) Formation With Ranitidine

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Effect of Oral Ranitidine on Urinary Excretion of N-Nitrosodimethylamine (NDMA) A Randomized Clinical Trial

Jeffry Florian et al.

Summary: This study involving 18 healthy participants found that oral ranitidine did not significantly increase urinary excretion of NDMA compared to placebo under different dietary conditions.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Editorial Material Medicine, General & Internal

Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation

C. Michael White et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Medicine, General & Internal

In Vitro Analysis of N-Nitrosodimethylamine (NDMA) Formation From Ranitidine Under Simulated Gastrointestinal Conditions

Zongming Gao et al.

Summary: The study found that conversion of ranitidine to NDMA was not detected until nitrite concentration reached 5000 μmol/L, which is 50-fold greater than the upper range of physiologic gastric nitrite concentrations at acidic pH. These findings suggest that ranitidine is not converted to NDMA in gastric fluid under physiologic conditions.

JAMA NETWORK OPEN (2021)

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Article Engineering, Environmental

Formation of NDMA from ranitidine and sumatriptan: The role of pH

Ruqiao Shen et al.

WATER RESEARCH (2013)

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Risk of N-Nitrosodimethylamine (NMDA) Formation With Ranitidine

相关参考文献

Effect of Oral Ranitidine on Urinary Excretion of N-Nitrosodimethylamine (NDMA) A Randomized Clinical Trial

Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation

In Vitro Analysis of N-Nitrosodimethylamine (NDMA) Formation From Ranitidine Under Simulated Gastrointestinal Conditions

Formation of NDMA from ranitidine and sumatriptan: The role of pH

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