期刊
INTERNATIONAL UROLOGY AND NEPHROLOGY
卷 53, 期 12, 页码 2459-2467出版社
SPRINGER
DOI: 10.1007/s11255-021-02999-0
关键词
Overactive bladder; Percutaneous tibial nerve stimulation
This study compared the efficacy of percutaneous tibial nerve stimulation with sham therapy for refractory OAB in non-neurogenic adult patients using a shortened 6-week treatment protocol. The results showed that PTNS therapy was more successful and effective than sham therapy, with a 52% success rate following the shortened 6-week protocol. PTNS treatment was also found to be safe and cost-effective compared to the conventional 12-week treatment.
Purpose It is a prospective randomized controlled trial comparing the efficacy of percutaneous tibial nerve stimulation versus sham for a shortened 6-week protocol of treatment in management of refractory OAB in non-neurogenic adult patients. Methods A total of 50 adults with refractory non-neurogenic overactive bladder symptoms were randomized 1:1 to 6 weeks of treatment with weekly percutaneous tibial nerve stimulation or sham therapy. Overactive bladder symptom score as well as 3-day voiding diaries were completed at baseline and at 7th week, 3rd and 6th month. Results The 7th week, 3rd and 6th month symptom score assessment for overall bladder symptoms demonstrated that percutaneous tibial nerve stimulation patients achieved statistically significant improvement in bladder symptoms with 52% reporting moderately improved responses compared to non-response of sham patients from baseline (P = 0.001). Voiding diary parameters after 6 weeks of therapy showed that PTNS patients had statistically significant improvements in frequency, voided volume and urgency urinary incontinence episodes compared to sham. No serious device-related adverse events or malfunctions were reported. Conclusion A shortened 6-week treatment protocol with PTNS appears to be successful and more effective than sham in the treatment of refractory OAB. PTNS therapy is safe and effective in treating OAB symptoms with 52% success rate following a shortened 6-week protocol. The duration of treatment with PTNS can be halved compared to the conventional 12 weeks, which would make it more acceptable and cost effective for patients.
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