期刊
INTERNATIONAL MATERIALS REVIEWS
卷 67, 期 7, 页码 765-795出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09506608.2022.2026860
关键词
Polyelectrolytes; electrostatic complexation; supramolecular assembly; heparin; dermatan sulfate; chondroitin sulfate; keratan sulfate; hyaluronic acid
资金
- Fundacao para a Ciencia e a Tecnologia [PTDC/BTM-MAT/28327/2017]
- Fundação para a Ciência e a Tecnologia [PTDC/BTM-MAT/28327/2017] Funding Source: FCT
The negative charge of glycosaminoglycans (GAG) allows them to form complexes with positively charged biomolecules and ions, regulating homeostatic functions. Copying these interactions enables the assembly of biofunctional devices with unprecedented biocompliance. However, there are challenges in complexing GAG into intricate three-dimensional networks.
The innate negative charge of glycosaminoglycans (GAG) is in the origin of their bioactivity: it drives their spontaneous complexation with positively charged biomolecules and ions, regulating homeostatic functions by protein stabilization, protection and activation. Copycatting these interactions enables different supramolecular approaches towards the assembly of biofunctional devices. Such approaches allow processing under physiological conditions and thus, they are of unprecedented biocompliance for device build-up compared to conventional methods based on chemical cross-linkers, volatile and organic solvents, and high temperatures. We review different set-ups based on GAG electrostatic complexation and showcase their application towards the development of diverse therapeutic systems. We also discuss challenges associated with GAG complexation into intricate three-dimensional networks holding back the widespread use of these methods. Finally, we anticipate that conscious choice of GAG with distinct polyanionic strength and specific bioactivity will make possible the fabrication of constructs with personalized and customized properties in the nearest future.
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