期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 72, 期 5, 页码 397-406出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2021.2018317
关键词
Anisotropic structure; cartilage cell adhesion; PLGA microspheres; PVA hydrogel
This study investigated the fabrication of anisotropic microsphere/hydrogel composites with improved and directed cell adhesion characteristics using a novel directional freezing-thawing (DFT) technique. The results showed that the DFT technique improved the compressive strength of the composite and enhanced the proliferation and adhesion of cultured cells.
The fabrication of bio tissues using anisotropic constructs capable of repairing and/or replacing diseased bio tissues remains a significant challenge in tissue engineering. Therefore, this study investigated the fabrication of an anisotropic PLGA-microspheres/PVA-hydrogel composite using a novel directional freezing-thawing (DFT) technique. The DFT technique altered the properties of the anisotropic PLGA-microspheres/PVA-hydrogel composite, such that its compressive strength improved from 14.64 +/- 1.09 MPa after three DFT cycles to 45.77 +/- 6.73 MPa after nine cycles. The utilization of the DFT technique was also shown to enhance the proliferation and adhesion of cultured chondrocyte cells. The obtained results demonstrated that DFT constituted a facile method to fabricate anisotropic microsphere/hydrogel composites with improved and directed cell adhesion characteristics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据