期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 608, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.121052
关键词
Hypocrellin; ROS-responsive; Sonodynamic therapy; Micelles; Triggered drug release
资金
- National Natural Science Foundation of China [82003181, 22074150]
- Social Development Program of Zhenjiang City [SH2019056]
Reactive oxygen species (ROS)-responsive micelles composed of poly (ethylene glycol)-poly(propylene sulfide) (PEG-PPS) can achieve targeted delivery and in situ release of drugs for cancer treatment, leading to effective growth inhibition through sonodynamic therapy (SDT).
Nanoparticles have been demonstrated to be effective in targeted drug delivery to tumor due to the enhanced permeability and retention (EPR) effect. However, the inhomogeneous distribution of the nanoparticles in the tumor and the slow release of the drug make the therapeutic effect unsatisfied. Here, we present reactive oxygen species (ROS)-responsive micelles comprising poly (ethylene glycol)-poly(propylene sulfide) (PEG-PPS) for targeted delivery and in situ release of drug. Upon the irradiation of ultrasound, the loaded sonosensitizer hypocrellin (HC) will generate ROS to trigger the disassembly of the micelles and meanwhile realize sonodynamic therapy (SDT) effect of cancer. The in vivo experiment indicates that the HC loaded PEG-PPS are biocompatible and much more efficacious than an equivalent amount of free HC in inhibiting the growth of cancer.
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