期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 609, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.121173
关键词
Injectable nanotherapeutics; Core-shell nanoparticles; Silica core; Phototherapy; Bioimaging
资金
- Department of Science and Technology (DST), Government of India [ECR/2016/001964]
- DST-SERB [PDF/2016/003329]
- Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India
- Parkinson's disease, and diabetes at NIPER-Ahmedabad
- [2020-7660]
This review highlights the potential of core-shell silica-based nanoparticles in developing next-generation therapeutics, covering their role in drug delivery, imaging, therapy, and challenges.
The core-shell silica-based nanoparticles (CSNPs) possess outstanding properties for developing next-generation therapeutics. CSNPs provide greater surface area owing to their mesoporous structure, which offers a high opportunity for surface modification. This review highlights the potential of core-shell silica-based nanoparticle (CSNP) based injectable nanotherapeutics (INT); its role in drug delivery, biomedical imaging, light-triggered phototherapy, Plasmonic enhancers, gene delivery, magnetic hyperthermia, immunotherapy, and potential as next-generation theragnostic. Specifically, the conceptual crosstalk on modern synthetic strategies, biodistribution profiles with a mechanistic view on the therapeutics loading and release modeling are dealt in detail. The manuscript also converses the challenges associated with CSNPs, regulatory hurdles, and their current market position.
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