期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 46, 期 3, 页码 476-485出版社
SPRINGERNATURE
DOI: 10.1038/s41366-021-01012-z
关键词
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资金
- Irish Health Research Board [HRC/2007/13]
- Breakthrough Cancer Research [BCR-2018-07 PH-UCC]
This study found that healthy lifestyle behaviors can have a protective effect against systemic inflammation in middle-to-older aged adults, independent of body weight. Maintaining a normal body mass index showed the most consistent associations with biomarkers.
Background/objectives Certain lifestyle behaviours may have a protective effect against low-grade systemic inflammation, which is linked to chronic disease. Our objective was to examine associations between a five-component protective lifestyle behaviour (PLB) score and a range of pro-inflammatory cytokines, adipocytokines, acute-phase response proteins, coagulation factors and white blood cells. Subjects/methods This was a cross-sectional study of 2045 middle-to-older aged men and women. Low-risk behaviours included never smoking, moderate alcohol intake, moderate-to-vigorous physical activity, a high-quality diet (upper 40% Dietary Approaches to Stop Hypertension score) and a normal body mass index (BMI) (18.5-24.9 kg/m(2)). Linear and logistic regression analyses tested individual protective behaviour and PLB score associations with biomarkers. Results Analysis of individual low-risk behaviours revealed varied associations depending on the biomarker, with normal BMI showing the most consistent associations. Examination of the PLB score showed that compared to subjects with 4-5 protective behaviours, those with 0-1 protective behaviours had 1.4-3.8 increased odds of having a less favourable inflammatory profile. Following adjustment for BMI, significant trend relationships were observed between the number of protective behaviours and complement component 3 (P < 0.001), c-reactive protein (P < 0.001), interleukin 6 (P < 0.001), tumour necrosis factor alpha (P < 0.001) and white blood cell count (P < 0.001) concentrations. Conclusions These results suggest a cumulative protective effect of healthy lifestyle behaviours against systemic inflammation in middle-to-older aged adults which is independent of having a healthy body weight.
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