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Towards Modeling Anhedonia and Its Treatment in Zebrafish

期刊

出版社

OXFORD UNIV PRESS
DOI: 10.1093/ijnp/pyab092

关键词

Anhedonia; animal models; antidepressant; behavior; zebrafish

资金

  1. Southwest University Zebrafish Platform Construction Funds (Chongqing, China)
  2. Programa de Excelencia Academica (PROEX)/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [23038.005450/2020-19]
  3. Program PQ-Gaucho Fundacao de Amparo a Pesquisa do Rio Grande do Sul (FAPERGS) [19/2551-0001764-2]
  4. FAPERGS [19/2551-0001-669-7]
  5. Zebrafish Platform Construction Fund from the Southwest University (Chongqing, China)
  6. state budgetary funds [121040200141-4]
  7. Russian Science Foundation [20-65-46006]
  8. Resource Fund of Applied Genetics MIPT [075-15-2021-684]
  9. Sirius University of Science and Technology
  10. Special Rector's Fellowship for SPSU students
  11. Russian Science Foundation [20-65-46006] Funding Source: Russian Science Foundation

向作者/读者索取更多资源

Mood disorders, particularly depression, are a leading cause of disability in humans. Anhedonia, the loss of pleasure, is a common and severe symptom of clinical depression. Experimental animal models are used extensively to understand the mechanisms of depression and develop new treatments, with rodents being widely validated. Zebrafish, as a model organism, is emerging as a powerful tool for studying affective disorders and modeling anhedonia, offering potential for translational research.
Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.

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