Patient-Independent Seizure Detection Based on Channel-Perturbation Convolutional Neural Network and Bidirectional Long Short-Term Memory

Automatic seizure detection is of great significance for epilepsy diagnosis and alleviating the massive burden caused by manual inspection of long-term EEG. At present, most seizure detection methods are highly patient-dependent and have poor generalization performance. In this study, a novel patient-independent approach is proposed to effectively detect seizure onsets. First, the multi-channel EEG recordings are preprocessed by wavelet decomposition. Then, the Convolutional Neural Network (CNN) with proper depth works as an EEG feature extractor. Next, the obtained features are fed into a Bidirectional Long Short-Term Memory (BiLSTM) network to further capture the temporal variation characteristics. Finally, aiming to reduce the false detection rate (FDR) and improve the sensitivity, the postprocessing, including smoothing and collar, is performed on the outputs of the model. During the training stage, a novel channel perturbation technique is introduced to enhance the model generalization ability. The proposed approach is comprehensively evaluated on the CHB-MIT public scalp EEG database as well as a more challenging SH-SDU scalp EEG database we collected. Segment-based average accuracies of 97.51% and 93.70%, event-based average sensitivities of 86.51% and 89.89%, and average AUC-ROC of 90.82% and 90.75% are yielded on the CHB-MIT database and SH-SDU database, respectively.

Automated summary

Automatic seizure detection is important for epilepsy diagnosis and reducing the burden of manual inspection. This study proposes a patient-independent approach using multi-channel EEG recordings, Convolutional Neural Network (CNN), and Bidirectional Long Short-Term Memory (BiLSTM) network for effective seizure onset detection, with postprocessing to improve performance. The approach is evaluated on two databases, achieving high accuracy, sensitivity, and AUC-ROC scores.