期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 16, 期 -, 页码 7249-7268出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S321800
关键词
graphene oxide; epsilon-poly-L-lysine; antibacterial; antibiofilm; electroplating
资金
- National Natural Science Foundation of China [82072402, 81672189]
- Natural Science Foundation of Shaanxi Province [2020JQ-965]
The study successfully coated graphene oxide and epsilon-poly-L-lysine on the surface of a CoCrMo alloy using a two-step electrodeposition method. The composite coating showed the best antibacterial and antibiofilm effects, offering a promising new approach to addressing implant infections in orthopedics and stomatology.
Introduction: With increases in implant infections, the search for antibacterial and biofilm coatings has become a new interest for orthopaedists and dentists. In recent years, graphene oxide (GO) has been extensively studied for its superior antibacterial properties. However, most of these studies have focused on solutions and there are few antibacterial studies on metal surfaces, especially the surfaces of cobalt-chromium-molybdenum (CoCrMo) alloys. epsilon-Poly-L-lysine (epsilon-PLL), as a novel food preservative, has a spectrum of antimicrobial activity; however, its antimicrobial activity after coating an implant surface is not clear. Methods: In this study, for the first time, a two-step electrodeposition method was used to coat GO and epsilon-PLL on the surface of a CoCrMo alloy. Its antibacterial and antibiofilm properties against S. aureus and E. coli were then studied. Results: The results show that the formation of bacteria and biofilms on the coating surface was significantly inhibited, GO and epsilon-PLL composite coatings had the best antibacterial and antibiofilm effects, followed by epsilon-PLL and GO coatings. In terms of classification, the coatings are anti-adhesive and contact-killingimhibitory surfaces. In addition to oxidative stress, physical damage to GO and electrostatic osmosis of epsilon-PLL are the main antibacterial and antibiofilm mechanisms. Discussion: This is the first study that GO and epsilon-PLL coatings were successfully prepared on the surface of CoCrMo alloy by electrodeposition. It provides a promising new approach to the problem of implant infection in orthopedics and stomatology.
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