期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijms222111579
关键词
antimicrobial blue light; resistance; tolerance; Escherichia coli; Klebsiella pneumoniae; Pseudomonas aeruginosa
资金
- National Science Centre
The study aimed to demonstrate the potential tolerance development in Gram-negative bacteria during antimicrobial blue light (aBL) treatment. Results showed that representative Gram-negative bacteria may develop tolerance to aBL, and the observed adaptation was a stable feature. Assays involving deficient mutants revealed possible mechanisms for aBL tolerance development.
Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential of tolerance/resistance development in Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa and demonstrated that representative Gram-negative bacteria may develop tolerance to aBL. The observed adaption was a stable feature. Assays involving E. coli K-12 tolC-, tolA-, umuD-, and recA-deficient mutants revealed some possible mechanisms for aBL tolerance development.
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