期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ijms23020844
关键词
Erdr1; TCR signal modulation; PLC gamma 1
资金
- Korea University [K1823521, K1917251]
The erythroid differentiation regulator 1 (Erdr1) enhances TCR signaling strength in CD4 T cells by promoting the activation and proliferation of T cells, amplifying Ca2+ influx and phosphorylation of PLC gamma 1, and promoting NFAT1 translocation into nuclei in the presence of TCR stimulation.
Erythroid differentiation regulator 1 (Erdr1) has previously been reported to control thymocyte selection via TCR signal regulation, but the effect of Erdr1 as a TCR signaling modulator was not studied in peripheral T cells. In this report, it was determined whether Erdr1 affected TCR signaling strength in CD4 T cells. Results revealed that Erdr1 significantly enhanced the anti-TCR antibody-mediated activation and proliferation of T cells while failing to activate T cells in the absence of TCR stimulation. In addition, Erdr1 amplified Ca2+ influx and the phosphorylation of PLC gamma 1 in CD4 T cells with the TCR stimuli. Furthermore, NFAT1 translocation into nuclei in CD4 T cells was also significantly promoted by Erdr1 in the presence of TCR stimulation. Taken together, our results indicate that Erdr1 positively modulates TCR signaling strength via enhancing the PLC gamma 1/Ca2+/NFAT1 signal transduction pathway.
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