4.7 Review

Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities

期刊

出版社

MDPI
DOI: 10.3390/ijms222111401

关键词

antibiofilm; anti-inflammatory; antimicrobial; antimicrobial peptides; mechanism of action

资金

  1. National Natural Science Foundation of China [31860607]

向作者/读者索取更多资源

Antimicrobial peptides (AMPs) are considered a new generation of antibiotics with not only antimicrobial activity but also antibiofilm, immune-regulatory, and other activities. Research on the mechanism of action of AMPs can aid in their modification and development, with many studies focusing on this area. AMPs exhibit a dual mechanism of action and possess antifibroblast and anti-inflammatory properties, making them a promising therapeutic prospect.
Antimicrobial peptides (AMPs) are regarded as a new generation of antibiotics. Besides antimicrobial activity, AMPs also have antibiofilm, immune-regulatory, and other activities. Exploring the mechanism of action of AMPs may help in the modification and development of AMPs. Many studies were conducted on the mechanism of AMPs. The present review mainly summarizes the research status on the antimicrobial, anti-inflammatory, and antibiofilm properties of AMPs. This study not only describes the mechanism of cell wall action and membrane-targeting action but also includes the transmembrane mechanism of intracellular action and intracellular action targets. It also discusses the dual mechanism of action reported by a large number of investigations. Antibiofilm and anti-inflammatory mechanisms were described based on the formation of biofilms and inflammation. This study aims to provide a comprehensive review of the multiple activities and coordination of AMPs in vivo, and to fully understand AMPs to realize their therapeutic prospect.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据