4.7 Review

Toll-Like Receptor Response to Hepatitis B Virus Infection and Potential of TLR Agonists as Immunomodulators for Treating Chronic Hepatitis B: An Overview

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

HBV-Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC

Geon-Woo Kim et al.

Summary: HBV significantly increases m(6)A modification of PTEN RNA, leading to a decrease in PTEN protein levels and affecting IRF-3 function and interferon synthesis. This finding provides new insights into HBV-mediated immune evasion and HBV-associated hepatocarcinogenesis.

HEPATOLOGY (2021)

Article Gastroenterology & Hepatology

Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B

Stephane Daffis et al.

Summary: GS-9688 treatment in woodchucks with WHV infection showed significant antiviral efficacy, with a >5 log(10) reduction in viral load and sustained response even after treatment cessation. The treatment also resulted in reduced intrahepatic WHV RNA and DNA levels, and enhanced immune responses in woodchucks.

HEPATOLOGY (2021)

Article Gastroenterology & Hepatology

Therapeutic Potential of TLR8 Agonist GS-9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators

Oliver E. Amin et al.

Summary: GS-9688 activates immune cell subsets and induces the production of immunomodulatory mediators in healthy controls and CHB patients. It boosts antiviral effector functions by activating HBV-specific CD8(+) T cells, CD4(+) follicular helper T cells, NK cells, and mucosal-associated invariant T cells. Additionally, GS-9688 modulates immunoregulatory subsets, potentially optimizing its antiviral efficacy.

HEPATOLOGY (2021)

Article Cell Biology

Hepatitis B virus particles activate B cells through the TLR2-MyD88-mTOR axis

Qian Li et al.

Summary: Host immune control is crucial in resolving primary hepatitis B virus (HBV) infections. This study found that TLR2 mRNA accumulation is most impacted during woodchuck hepatitis virus (WHV) infection resolution, with B-cell TLR2 activation playing a key role in HBV infection resolution.

CELL DEATH & DISEASE (2021)

Article Multidisciplinary Sciences

Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition

Li Zhou et al.

Summary: Glucose metabolism and innate immunity have co-evolved, but the mechanisms of interaction during HBV infection remain unclear. This study shows that HBV can inhibit RIG-I/MAVS signaling pathway by enhancing glycolysis and lactate production, leading to immune evasion. Lactate binds MAVS, preventing its mitochondrial localization and interfering with antiviral immune response to HBV.

NATURE COMMUNICATIONS (2021)

Article Engineering, Biomedical

Delivery of toll-like receptor 3 ligand poly(I:C) to the liver by calcium phosphate nanoparticles conjugated with an F4/80 antibody exerts an anti-hepatitis B virus effect in a mouse model

Yanqin Du et al.

Summary: Nanoparticles carrying poly(I:C) conjugated with an F4/80 antibody showed enhanced liver targeting and significantly reduced HBV levels in mice, suggesting a promising alternative for future anti-HBV treatment.

ACTA BIOMATERIALIA (2021)

Article Biotechnology & Applied Microbiology

Long-term immune protection against HBV: associated factors and determinants

Marianna Mastrodomenico et al.

Summary: The study found that vaccination against hepatitis B at the age of 12 significantly increased protective antibody titers, playing an important role in protection, and could still remain effective even 20 years after vaccination.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

Article Immunology

Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex

Feiyan Deng et al.

Summary: This study reveals a novel mechanism by which HBsAg interacts with the TAK1-TAB2 complex to suppress the activation of the NF-kappa B signaling pathway, facilitating HBV evasion from immune responses. Autophagic degradation of TAK1 and TAB2 by HBsAg is identified as a key process involved in this mechanism. These findings provide new insights into the pathogenesis of chronic hepatitis B.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

TLR Agonists as Mediators of Trained Immunity: Mechanistic Insight and Immunotherapeutic Potential to Combat Infection

Allison M. Owen et al.

Summary: Despite improvements in critical care medicine, infection remains a significant challenge, especially for immunocompromised patients who are highly susceptible to severe infection leading to sepsis. Activation of the innate immune system, particularly through the phenomenon of trained immunity, shows promise in enhancing host immune defenses. Toll-like receptor (TLR) agonists have been identified as agents capable of inducing trained immunity through metabolic and epigenetic modifications, offering potential as immunotherapeutic agents in combatting infection.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biotechnology & Applied Microbiology

Emerging concepts in the science of vaccine adjuvants

Bali Pulendran et al.

Summary: Adjuvants are vaccine components that enhance the immune response. Recent advances in understanding the molecular mechanisms and systems vaccinology have revitalized the science and development of novel adjuvants for use in vaccines against COVID-19 and future pandemics.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Virology

Treatment with the Immunomodulator AIC649 in Combination with Entecavir Produces Antiviral Efficacy in the Woodchuck Model of Chronic Hepatitis B

Kyle E. Korolowicz et al.

Summary: Current interventions for chronic hepatitis B (CHB) are not curative, so more effective drugs are needed. A study on woodchucks showed that AIC649, an immunomodulator, reduced viral DNA and surface antigen levels effectively. Combining AIC649 with Entecavir demonstrated superior viral control and improved antiviral immune responses, supporting its potential in treating human CHB.

VIRUSES-BASEL (2021)

Article Immunology

Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes

Liyuan Wang et al.

Summary: ADAR1 interacts with HBV RNA to disrupt host immune recognition through deamination, promoting HBV replication. HBV X protein transcriptionally increases ADAR1 expression to raise the threshold for immune activation, enhancing HBV escape from immune recognition.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Immunology

Influence of Pattern Recognition Receptor Ligands on Induction of Innate Immunity and Control of Hepatitis B Virus Infection

Sahar Asadi-Asadabad et al.

Summary: The study revealed that different pattern recognition receptor agonists have varying effects on inhibiting chronic hepatitis B, with Poly(I:C)-HMW and Poly(I:C)-HMW/LyoVec showing significant inhibitory effects on HBV, while others did not show significant effects.

VIRAL IMMUNOLOGY (2021)

Article Medicine, Research & Experimental

SIGLEC-3 (CD33) serves as an immune checkpoint receptor for HBV infection

Tsung-Yu Tsai et al.

Summary: Chronic hepatitis B infection is difficult to eliminate with current antiviral medications. Research shows that a specific antigen in HBV can induce immunosuppression by binding to SIGLEC-3, and certain genetic variations may increase the risk of hepatocellular carcinoma in CHB patients. Blocking SIGLEC-3 could potentially reactivate host immunity to HBV and reduce the incidence of HCC in this patient population.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Medicine, Research & Experimental

A novel TLR7 agonist as adjuvant to stimulate high quality HBsAg-specific immune responses in an HBV mouse model

Yunlong Hu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Article Engineering, Biomedical

Genetic immunization against hepatitis B virus with calcium phosphate nanoparticles in vitro and in vivo

Leonardo Rojas-Sanchez et al.

ACTA BIOMATERIALIA (2020)

Review Biochemistry & Molecular Biology

Toll-like Receptors and the Control of Immunity

Katherine A. Fitzgerald et al.

Article Medicine, Research & Experimental

A Single and Multiple Ascending Dose Study of Toll-Like Receptor 7 Agonist (RO7020531) in Chinese Healthy Volunteers

Andrea Luk et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2020)

Review Immunology

Checkpoint Inhibitors and Therapeutic Vaccines for the Treatment of Chronic HBV Infection

Ruben C. Hoogeveen et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Pharmacology & Pharmacy

Mechanisms of HBV immune evasion

Adrian Kuipery et al.

ANTIVIRAL RESEARCH (2020)

Article Biochemistry & Molecular Biology

N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling

Geon-Woo Kim et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Multidisciplinary Sciences

Increased vaccine tolerability and protection via NF-κB modulation

B. A. Moser et al.

SCIENCE ADVANCES (2020)

Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Meeting Abstract Gastroenterology & Hepatology

First in Human, single ascending dose clinical trial of AIC649 in patients with chronic hepatitis

Ibironke Addy et al.

JOURNAL OF HEPATOLOGY (2019)

Article Gastroenterology & Hepatology

Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection

Adam J. Gehring et al.

GASTROENTEROLOGY (2019)

Article Gastroenterology & Hepatology

Hepatitis B Virus Does Not Interfere With Innate Immune Responses in the Human Liver

Aleksei Suslov et al.

GASTROENTEROLOGY (2018)

Article Gastroenterology & Hepatology

HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon

Pascal Mutz et al.

GASTROENTEROLOGY (2018)

Article Biochemistry & Molecular Biology

TLR agonist combinations that stimulate Th type I polarizing responses from human neonates

Naveen Surendran et al.

INNATE IMMUNITY (2018)

Article Gastroenterology & Hepatology

Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B

Harry L. A. Janssen et al.

JOURNAL OF HEPATOLOGY (2018)

Article Multidisciplinary Sciences

Direct antiviral properties of TLR ligands against HBV replication in immune-competent hepatocytes

Julie Lucifora et al.

SCIENTIFIC REPORTS (2018)

Article Biochemical Research Methods

CpG oligonucleotides increase HBV-specific cytokine responses in whole blood and enhance cytokine release assay sensitivity

Werner Dammermann et al.

JOURNAL OF VIROLOGICAL METHODS (2017)

Article Virology

Interferon-β response is impaired by hepatitis B virus infection in Tupaia belangeri

Mohammad Enamul Hoque Kayesh et al.

VIRUS RESEARCH (2017)

Article Immunology

Hepatitis B virus antigens impair NK cell function

Yinli Yang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

Article Biochemistry & Molecular Biology

Innate immune evasion by hepatitis B virus-mediated downregulation of TRIF

Yun Hong et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Gastroenterology & Hepatology

The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection

Edward J. Gane et al.

JOURNAL OF HEPATOLOGY (2015)

Article Gastroenterology & Hepatology

Early inhibition of hepatocyte innate responses by hepatitis B virus

Souphalone Luangsay et al.

JOURNAL OF HEPATOLOGY (2015)

Article Medicine, Research & Experimental

Immune Response in Hepatitis B Virus Infection

Anthony Tan et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

Article Medicine, Research & Experimental

Hepadnavirus Genome Replication and Persistence

Jianming Hu et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

Article Virology

Innate and Adaptive Immune Regulation During Chronic Viral Infections

Elina I. Zuniga et al.

ANNUAL REVIEW OF VIROLOGY, VOL 2 (2015)

Article Microbiology

STING Agonists Induce an Innate Antiviral Immune Response against Hepatitis B Virus

Fang Guo et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

Article Multidisciplinary Sciences

AIC649 Induces a Bi-Phasic Treatment Response in the Woodchuck Model of Chronic Hepatitis B

Daniela Paulsen et al.

PLOS ONE (2015)

Review Medicine, General & Internal

TLR9: an important molecule in the fight against hepatitis B virus

Aziz Shahrakyvahed et al.

POSTGRADUATE MEDICAL JOURNAL (2014)

Editorial Material Gastroenterology & Hepatology

BASIC AND TRANSLATIONAL-LIVER

Robert E. Lanford et al.

GASTROENTEROLOGY (2013)

Review Gastroenterology & Hepatology

The Molecular Virology of Hepatitis B Virus

Dieter Glebe et al.

SEMINARS IN LIVER DISEASE (2013)

Article Gastroenterology & Hepatology

Hepatocyte polarization is essential for the productive entry of the hepatitis B virus

Andreas Schulze et al.

HEPATOLOGY (2012)

Article Gastroenterology & Hepatology

Transcriptomic analysis of the woodchuck model of chronic hepatitis B

Simon P. Fletcher et al.

HEPATOLOGY (2012)

Article Virology

Pattern recognition receptor responses in children with chronic hepatitis B virus infection

Ida Louise Heiberg et al.

JOURNAL OF CLINICAL VIROLOGY (2012)

Article Multidisciplinary Sciences

Hepatitis B Virus Impairs TLR9 Expression and Function in Plasmacytoid Dendritic Cells

Isabelle E. Vincent et al.

PLOS ONE (2011)

Review Immunology

TLR-based immune adjuvants

Folkert Steinhagen et al.

VACCINE (2011)

Review Biochemistry & Molecular Biology

Pattern Recognition Receptors and Inflammation

Osamu Takeuchi et al.

Review Immunology

Immunity and immunopathology to viruses: what decides the outcome?

Barry T. Rouse et al.

NATURE REVIEWS IMMUNOLOGY (2010)

Article Gastroenterology & Hepatology

Temporal Analysis of Early Immune Responses in Patients With Acute Hepatitis B Virus Infection

Claire Dunn et al.

GASTROENTEROLOGY (2009)

Article Gastroenterology & Hepatology

Hepatitis B: The Virus and Disease

T. Jake Liang

HEPATOLOGY (2009)

Article Gastroenterology & Hepatology

Regulation of toll-like receptor-2 expression in chronic hepatitis B by the precore protein

Kumar Visvanathan et al.

HEPATOLOGY (2007)

Article Immunology

Reduced expression of toll-like receptor 2 on peripheral monocytes in patients with chronic hepatitis B

Stephen M. Riordan et al.

CLINICAL AND VACCINE IMMUNOLOGY (2006)

Article Virology

Animal models for the study of HBV replication and its variants

M. Dandri et al.

JOURNAL OF CLINICAL VIROLOGY (2005)

Review Virology

Stealth and cunning: Hepatitis B and hepatitis C viruses

SF Wieland et al.

JOURNAL OF VIROLOGY (2005)

Review Gastroenterology & Hepatology

Epidemiology and natural history of hepatitis B

BJ McMahon

SEMINARS IN LIVER DISEASE (2005)

Article Multidisciplinary Sciences

Genomic analysis of the host response to hepatitis B virus infection

S Wieland et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Immunology

Toll-like receptor control of the adaptive immune responses

A Iwasaki et al.

NATURE IMMUNOLOGY (2004)

Review Gastroenterology & Hepatology

Kinetics of the immune response during HBV and HCV infection

A Bertoletti et al.

HEPATOLOGY (2003)

Review Immunology

Toll-like receptors and innate immunity

R Medzhitov

NATURE REVIEWS IMMUNOLOGY (2001)

Review Medicine, General & Internal

Advances in immunology: Innate immunity.

R Medzhitov et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)