期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/ijms23010072
关键词
MDA-7; IL-24; cytokine; apoptosis; bystander antitumor activity; combinatorial therapy
资金
- Virginia Catalyst
- InterLeukin Combinatorial Therapies, Inc.
- National Foundation for Cancer Research
- NIH/NCI [R01 CA244993, R01 CA259599]
MDA-7/IL-24 is a potent tumor suppressor with multiple functions, including inhibition of tumor growth, invasion, angiogenesis, and metastasis, induction of bystander antitumor activity, and synergy with conventional cancer therapeutics.
Melanoma differentiation associated gene-7/interleukin-24 (MDA-7/IL-24), a secreted protein of the IL-10 family, was first identified more than two decades ago as a novel gene differentially expressed in terminally differentiating human metastatic melanoma cells. MDA-7/IL-24 functions as a potent tumor suppressor exerting a diverse array of functions including the inhibition of tumor growth, invasion, angiogenesis, and metastasis, and induction of potent bystander antitumor activity and synergy with conventional cancer therapeutics. MDA-7/IL-24 induces cancer-specific cell death through apoptosis or toxic autophagy, which was initially established in vitro and in preclinical animal models in vivo and later in a Phase I clinical trial in patients with advanced cancers. This review summarizes the history and our current understanding of the molecular/biological mechanisms of MDA-7/IL-24 action rendering it a potent cancer suppressor.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据