4.7 Article

Functional Recovery Caused by Human Adipose Tissue Mesenchymal Stem Cell-Derived Extracellular Vesicles Administered 24 h after Stroke in Rats

期刊

出版社

MDPI
DOI: 10.3390/ijms222312860

关键词

human adipose tissue mesenchymal stem cells; extracellular vesicles; experimental ischemic stroke; intranasal treatment; neuroprotection; functional recovery

资金

  1. Instituto Nacional de Ciencia e Tecnologia-INCT-EN [2014-465671/2014-4]
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
  3. Coordenacao de Aperfeicoamento de pessoal de Nivel Superior-CAPES
  4. Fundacao de Amparo a pesquisa do Estado do Rio Grande do Sul-FAPERGS
  5. Universidade Federal do Rio Grande do Sul-UFRGS
  6. Ministerio da Saude

向作者/读者索取更多资源

Nasally administered human adipose tissue mesenchymal stem cell-derived extracellular vesicles show potential neuroprotective properties in ischemic stroke, improving the blood-brain barrier, reducing infarct volume, and recovering motor and behavioral impairment.
Ischemic stroke is a major cause of death and disability, intensely demanding innovative and accessible therapeutic strategies. Approaches presenting a prolonged period for therapeutic intervention and new treatment administration routes are promising tools for stroke treatment. Here, we evaluated the potential neuroprotective properties of nasally administered human adipose tissue mesenchymal stem cell (hAT-MSC)-derived extracellular vesicles (EVs) obtained from healthy individuals who underwent liposuction. After a single intranasal EV (200 mu g/kg) administered 24 h after a focal permanent ischemic stroke in rats, a higher number of EVs, improvement of the blood-brain barrier, and re-stabilization of vascularization were observed in the recoverable peri-infarct zone, as well as a significant decrease in infarct volume. In addition, EV treatment recovered long-term motor (front paws symmetry) and behavioral impairment (short- and long-term memory and anxiety-like behavior) induced by ischemic stroke. In line with these findings, our work highlights hAT-MSC-derived EVs as a promising therapeutic strategy for stroke.

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