4.7 Article

Adenylate Kinase 4-A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds

Zhaowu Ma et al.

Summary: Rapid progress in molecular cancer biology and the discovery of new oncology drugs have opened new opportunities for cancer target discovery. HIF-1, a crucial signaling pathway related to tumorigenesis, regulates the activity of many transcription factors and downstream molecules that affect tumor growth and metastasis. Overexpression of HIF-1 alpha is strongly associated with poor prognosis in several solid cancers. Pharmacological targeting of the HIF-1 signaling pathway has been considered a new strategy for cancer therapy, but translation into clinically available treatments remains challenging.

SEMINARS IN CANCER BIOLOGY (2022)

Article Multidisciplinary Sciences

HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics

Xin Yi Chan et al.

Summary: Heterozygous gain-of-function mutations of HIF2A are associated with vascular pathology independent of erythrocytosis. The aberrant phenotype of HIF2A-SMCs was identified, while Hif2AGOF mice displayed pulmonary hypertension and differences in pulmonary arterial smooth muscle cells. Targeting vascular aberrations may benefit patients with HIF2A GOF mutations.

ISCIENCE (2021)

Article Immunology

Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1α and AMPK in Macrophages

Wei-Yao Chin et al.

Summary: Macrophages are divided into classically activated M1 and alternatively activated M2 types, with Ak4 playing a crucial role in regulating inflammation gene expression and cellular function in M1 macrophages.

FRONTIERS IN IMMUNOLOGY (2021)

Article Physiology

The hallmarks of severe pulmonary arterial hypertension: the cancer hypothesis-ten years later

Carlyne D. Cool et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

Glycolysis - a key player in the inflammatory response

Gonzalo Soto-Heredero et al.

FEBS JOURNAL (2020)

Review Oncology

Adenylate Kinase and Metabolic Signaling in Cancer Cells

Aleksandr Klepinin et al.

FRONTIERS IN ONCOLOGY (2020)

Article Endocrinology & Metabolism

NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD

Michael Seimetz et al.

NATURE METABOLISM (2020)

Review Biochemistry & Molecular Biology

Hypoxia signaling in human diseases and therapeutic targets

Jae W. Lee et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

Article Medicine, Research & Experimental

Adenylate kinase 4 promotes bladder cancer cell proliferation and invasion

Feng Xin et al.

CLINICAL AND EXPERIMENTAL MEDICINE (2019)

Article Respiratory System

Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension

Cheng-Jun Hu et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Article Biotechnology & Applied Microbiology

AK4 Promotes the Progression of HER2-Positive Breast Cancer by Facilitating Cell Proliferation and Invasion

Jie Zhang et al.

DISEASE MARKERS (2019)

Article Multidisciplinary Sciences

Prognostic and therapeutic potential of Adenylate kinase 2 in lung adenocarcinoma

Huibin Liu et al.

SCIENTIFIC REPORTS (2019)

Article Respiratory System

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

Marc Humbert et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Article Respiratory System

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

Gerald Simonneau et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Review Biochemistry & Molecular Biology

Adenylate Kinase: A Ubiquitous Enzyme Correlated with Medical Conditions

Mihaela Ileana Ionescu

PROTEIN JOURNAL (2019)

Review Medicine, General & Internal

Thin Air, Thick Vessels: Historical and Current Perspectives on Hypoxic Pulmonary Hypertension

Jason M. Young et al.

FRONTIERS IN MEDICINE (2019)

Article Biochemistry & Molecular Biology

Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors

Koichi Oshima et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Review Medicine, Research & Experimental

Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains

Miranda K. Culley et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Multidisciplinary Sciences

High-resolution Respirometry to Assess Mitochondrial Function in Permeabilized and Intact Cells

Siamak Djafarzadeh et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2017)

Review Medicine, General & Internal

Emerging Metabolic Therapies in Pulmonary Arterial Hypertension

Lloyd D. Harvey et al.

JOURNAL OF CLINICAL MEDICINE (2017)

Article Critical Care Medicine

From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics Targeting Cell Growth and Proliferation Signaling Hubs

Soni Savai Pullamsettit et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

Article Oncology

Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4

Koichi Fujisawa et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2016)

Article Critical Care Medicine

Regulation of Hypoxia-induced Pulmonary Hypertension by Vascular Smooth Muscle Hypoxia-Inducible Factor-1α

Molly K. Ball et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

Review Cardiac & Cardiovascular Systems

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

Marlene Rabinovitch et al.

CIRCULATION RESEARCH (2014)

Review Biochemistry & Molecular Biology

The many isoforms of human adenylate kinases

Christakis Panayiotou et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells

Fanzhi Kong et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2013)

Review Respiratory System

Pathogenesis of pulmonary arterial hypertension: lessons from cancer

Christophe Guignabert et al.

EUROPEAN RESPIRATORY REVIEW (2013)

Article Pathology

Paxillin Regulates Pulmonary Arterial Smooth Muscle Cell Function in Pulmonary Hypertension

Christine Veith et al.

AMERICAN JOURNAL OF PATHOLOGY (2012)

Article Biochemistry & Molecular Biology

Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4

Christakis Panayiotou et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase

Rujuan Liu et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Review Biochemistry & Molecular Biology

Adenylate Kinase and AMP Signaling Networks: Metabolic Monitoring, Signal Communication and Body Energy Sensing

Petras Dzeja et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2009)

Review Cardiac & Cardiovascular Systems

Hypoxia-induced pulmonary vascular remodeling - Cellular and molecular mechanisms

Kurt R. Stenmark et al.

CIRCULATION RESEARCH (2006)

Article Cardiac & Cardiovascular Systems

Thrombin and NAD(P)H oxidase-mediated regulation of CD44 and BMP4-Id pathway in VSMC, restenosis, and atherosclerosis

Aleksandr E. Vendrov et al.

CIRCULATION RESEARCH (2006)