期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijms222111713
关键词
DSB induction; ultrasoft X-rays; DNA repair; enzymatic DSB
资金
- Chung Shan Medical University, Taichung, TaiwanChung Shan Medical University, Taichung, Taiwan [CSMU-INT-109-08]
- Chang Gung Memorial Hospital at Linkou, Taiwan [CMRPD1H0473, CMRPD1J0322]
- Ministry of Sciences and Technology, Taiwan [MOST 109-2314-B-182-078-MY3, 110-2628-B-182-008]
- Ministry of Sciences and Technology, Taiwan [MOST 108-2638-E-005-001-MY2]
This study estimated the yields of DNA double-strand breaks (DSBs) induced by ultrasoft X-rays, evaluated their relative biological effectiveness (RBE) and repair outcomes, and compared them to Co-60 gamma-rays. The results showed higher RBE values for ultrasoft X-rays under different conditions, indicating a potential advantage in cancer treatment through the synergistic effects of DSB induction and enzymatic DSB formation.
This paper estimates the yields of DNA double-strand breaks (DSBs) induced by ultrasoft X-rays and uses the DSB yields and the repair outcomes to evaluate the relative biological effectiveness (RBE) of ultrasoft X-rays. We simulated the yields of DSB induction and predicted them in the presence and absence of oxygen, using a Monte Carlo damage simulation (MCDS) software, to calculate the RBE. Monte Carlo excision repair (MCER) simulations were also performed to calculate the repair outcomes (correct repairs, mutations, and DSB conversions). Compared to Co-60 gamma-rays, the RBE values for ultrasoft X-rays (titanium K-shell, aluminum K-shell, copper L-shell, and carbon K-shell) for DSB induction were respectively 1.3, 1.9, 2.3, and 2.6 under aerobic conditions and 1.3, 2.1, 2.5, and 2.9 under a hypoxic condition (2% O-2). The RBE values for enzymatic DSBs were 1.6, 2.1, 2.3, and 2.4, respectively, indicating that the enzymatic DSB yields are comparable to the yields of DSB induction. The synergistic effects of DSB induction and enzymatic DSB formation further facilitate cell killing and the advantage in cancer treatment.
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