The Role of Oxidative Stress in Sarcoidosis

Sarcoidosis is a rare, systemic inflammatory disease whose diagnosis and management can pose a challenge for clinicians and specialists. Scientific knowledge on the molecular pathways that drive its development is still lacking, with no standardized therapies available and insufficient strategies to predict patient outcome. In recent years, oxidative stress has been highlighted as an important factor in the pathogenesis of sarcoidosis, involving several enzymes and molecules in the mechanism of the disease. This review presents current data on the role of oxidative stress in sarcoidosis and its interaction with inflammation, as well as the application of antioxidative therapy in the disease.

Automated summary

Sarcoidosis is a rare systemic inflammatory disease with limited scientific knowledge on its molecular pathways. Oxidative stress has been identified as a key factor in its pathogenesis, involving various enzymes and molecules. Antioxidative therapy may play a role in the management of sarcoidosis.