期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijms222111538
关键词
mitogen-activated protein kinase; dual-specificity phosphatase; MAP kinase phosphatase; sex differences; metabolic syndromes; cancer; therapy
资金
- Fondation Groupama pour la Sante
- Region Nouvelle-Aquitaine [2018-1R30114]
- La Fondation ARC pour la Recherche sur le Cancer [PJA 20191209631]
- Ligue Nationale contre le Cancer [AAPPEAC2018.LCC/CG]
- Groupama Centre-Atlantique
Mitogen-activated protein kinases (MAPKs) are crucial for cell functioning, with DUSP9 playing a significant role in regulating MAPK activity. Dysregulation of MAPKs by phosphatases like DUSP9 can lead to various human pathologies, emphasizing the importance of careful regulation in maintaining proper cell functioning.
Mitogen-activated protein kinases (MAPKs) are essential for proper cell functioning as they regulate many molecular effectors. Careful regulation of MAPKs is therefore required to avoid MAPK pathway dysfunctions and pathologies. The mammalian genome encodes about 200 phosphatases, many of which dephosphorylate the MAPKs and bring them back to an inactive state. In this review, we focus on the normal and pathological functions of dual-specificity phosphatase 9 (DUSP9)/MAP kinase phosphatases-4 (MKP-4). This cytoplasmic phosphatase, which belongs to the threonine/tyrosine dual-specific phosphatase family and was first described in 1997, is known to dephosphorylate ERK1/2, p38, JNK and ASK1, and thereby to control various MAPK pathway cascades. As a consequence, DUSP9 plays a major role in human pathologies and more specifically in cardiac dysfunction, liver metabolic syndromes, diabetes, obesity and cancer including drug response and cell stemness. Here, we recapitulate the mechanism of action of DUSP9 in the cell, its levels of regulation and its roles in the most frequent human diseases, and discuss its potential as a therapeutic target.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据